Analytical Variability of Biological Parameters of Exposure and Early Effects

  • R. F. M. Herber
  • K.-H. Schaller
Conference paper
Part of the International Archives of Occupational and Environmental Health Supplement book series (OCCUPATIONAL)

Abstract

In occupational medicine, the objective of any examination is to obtain a finding which can be related to the individual subject. In the case of exposure to hazardous substances, this finding is usually the result of an analytical determination of:
  1. 1.

    The concentration of the substance itself in various biological media (blood, urine, expired air, hair, fingernails, adipose tissue and saliva)

     
  2. 2.

    The concentration products (metabolites) in the same media (1 and 2: biological parameters of exposure) (Lauwerys 1983)

     
  3. 3.

    Biological parameters of early effects that are the result of the reaction of the organism to exposure (biological parameters of early effects) (Lauwerys 1983)

     
and/or the assessment of the health risk by estimating the external exposure to the chemical, i.e. ambient monitoring of the airborne concentration of the chemical (Zielhuis 1985).

Keywords

HPLC Urea Cobalt Rubber Alkane 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • R. F. M. Herber
  • K.-H. Schaller

There are no affiliations available

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