Trauma-Induced Alterations of the Lymphokine Cascade

  • E. Faist
  • W. Ertel
  • A. Mewes
  • S. Alkan
  • A. Walz
  • T. Strasser


With increasing knowledge about the fundamental importance of cytokines for the regulation of almost all immune responses, new avenues for the better understanding of trauma-induced alterations of cell-mediated immune response mechanisms have been made accessible. The biochemical and biological characterization of mediators and the resulting possibilities for their species-specific recombination were preconditions for the availability and the feasibility of reproducible studies of mediator behavior in pathological states of hemorrhagic shock and trauma.


Major Trauma Cyclooxygenase Inhibitor Cytokine Synthesis Mediator Behavior Macro Phage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Abraham E, Regan RF (1985) The effects of hemorrhage and trauma on interleukin 2 production. Arch Surg 120: 1341–1344PubMedCrossRefGoogle Scholar
  2. 2.
    Akiyoshi T, Koba F, Arinaga S et al. (1985) Impaired production of interleukin-2 after surgery. Clin Exp Immunol 59: 45–49PubMedGoogle Scholar
  3. 3.
    Antonacci AC (1984) How do immunomodulators affect host defense in the burn patient? J Trauma 24: 101–105CrossRefGoogle Scholar
  4. 4.
    Bonney RJ, Davies P (1984) Possible autoregulatory functions of the secretory products on mononuclear phagocytes. In: Adams DO, Hanna MG Jr (eds) Contemporary topics in immunology, vol 13. Plenum, New York, p 199Google Scholar
  5. 5.
    Boraschi D, Censini S, Tagliabue A (1984) Interferon reduces macrophage-suppressive activity by inhibiting prostaglandin E2 release and inducing interleukin 1 production. J Immunol 133: 764–768PubMedGoogle Scholar
  6. 6.
    Cahill J, Hopper KE (1982) Immunoregulation by macrophages: differential secretion of prostaglandin E and interleukin during infection with Salmonella enteritidis. Cell Immunol 67: 229–240PubMedCrossRefGoogle Scholar
  7. 7.
    Chouaib S, Fradelizi D (1982) The mechanism of inhibition of human IL-2 production. J Immunol 129: 2463–2468PubMedGoogle Scholar
  8. 8.
    Chouaib S, Chateroud L, Klatzman D et al. (1984) The mechanisms of inhibition of human IL-2 production. II PGE2 induction of suppressor T-lymphocytes. J Immunol 132: 1851–1852PubMedGoogle Scholar
  9. 9.
    Faist E, Mewes A, Baker CC et al. (1987) Prostaglandin E2 (PGE2)-dependent suppression of interleukin 2 (IL-2) production in patients with major trauma. J Trauma 27: 837PubMedCrossRefGoogle Scholar
  10. 10.
    Faist E, Kupper T, Baker CC et al. (1986) Depression of cellular immunity after major injury: its association with posttraumatic complications and its reversal with immuno- modulation. Arch Surg 121: 1000–1005PubMedCrossRefGoogle Scholar
  11. 11.
    Faist E, Mewes A, Strasser Th, Alkan S et al. (1988) Alteration of monocyte (Mø) function following major injury. Arch Surg 123, 3: 287Google Scholar
  12. 12.
    Farrar J J, Benjamin WR, Hilfiker M et al. (1982) The biochemistry, biology and role of Interleukin-2 in the induction of cytotoxic T-cell and antibody forming B-cell responses. Immunol Rev 62: 129CrossRefGoogle Scholar
  13. 13.
    Fischer A, Dupandy A, Griscelli C (1981) Role of prostaglandin E2 in the induction of nonspecific T lymphocyte suppressor activity. J Immunol 126: 1452–1455PubMedGoogle Scholar
  14. 14.
    Goodwin JS, Bankhurst AD, Messner RP (1977) Suppression of human T-cell mitogenesis by prostaglandin: existence of a prostaglandin producing suppressor cell. J Exp Med 146: 1719PubMedCrossRefGoogle Scholar
  15. 15.
    Goodwin JS, Webb DR (1980) Regulation of the immune response by prostaglandins. Clin Immunol Immunopathol 15: 106–122PubMedCrossRefGoogle Scholar
  16. 16.
    Grabstein K, Eisenman J, Mochizaki D et al. (1985) Purification to homogeneity of a B-cell stimulating factor. J Exp Med 163: 1405CrossRefGoogle Scholar
  17. 17.
    Grbic JT, Wood JJ, Jordan AJ et al., (1985) Lymphocytes from burn patients are more sensitive to suppression by prostaglandin E2. Surg Forum 108Google Scholar
  18. 18.
    Greene DR, Chue B, Ferguson TA et al. (1985) Production of an antigenspecific component of suppressor inducer factor by a helper T-cell clone: possible role for IL-1 at the interface of immunity and tolerance. Br J Rheumatol 26: 74–79Google Scholar
  19. 19.
    Howard M, Nakanishi K, Paul WE (1984) B-cell growth and differentiation factors. Immunol Rev 78: 185PubMedCrossRefGoogle Scholar
  20. 20.
    Howard M, Farrar J, Hilfiker M et al. (1982) Identification of T-cell derived B-cell growth factor distinct from interleukin-2. J Exp Med 55: 914CrossRefGoogle Scholar
  21. 21.
    Kupper TS, Green DR, Durum SK et al. (1985) Defective antigen presentation to a cloned T-helper cell by macrophages from burned mice can be restored with interleukin 1. Surgery 98: 199–206PubMedGoogle Scholar
  22. 22.
    Miller CL, Fink MP et al. (1988) Mechanisms of altered monocyte prostaglandin E2 production in severely injured patients. Arch Surg 123: 293CrossRefGoogle Scholar
  23. 23.
    Miller CL (1981) Secondary immunodeficiency in burns and after surgical trauma. Clin Immunol Allergy 1: 641–667Google Scholar
  24. 24.
    Neef JR, Curl GR, Woody JN (1981) Absolute requirements for adherent cells in the production of human IL-2. Cell Immunol 3: 142–150Google Scholar
  25. 25.
    Ninnemann JL (1984) Prostaglandins and immunity: prostaglandins in inflammation and disease. Immunol Today 5: 170CrossRefGoogle Scholar
  26. 26.
    Ninnemann JL, Stockland AE (1984) Participation of prostaglandin E2 in immunosuppression following thermal injury. J Trauma 24: 201–207PubMedCrossRefGoogle Scholar
  27. 27.
    Ozer H, Cowens JW, Calvin M et al. (1982) In vitro effects of hydroperoxy-cyclophosphamide on human immunoregulatory subset function. J Exp Med 155: 276PubMedCrossRefGoogle Scholar
  28. 28.
    Picker LJ, Raff HV, Goldyne ME, Stabo JD (1980) Metabolic heterrogeneity among human monocytes and its modulation by PGE2. J Immunol 124: 2557PubMedGoogle Scholar
  29. 29.
    Rice LA, Laughter AU, Twomey JJ (1979) Three suppressor systems in human blood that modulate lymphoproliferation. J Immunol 122: 991PubMedGoogle Scholar
  30. 30.
    Rosenberg S, Lipsky PE (1981) Macrophage-lymphocyte cooperation in human immune responses. In: Dingle JT, Gordon JL (eds) Cellular interactions. Elsevier, AmsterdamGoogle Scholar
  31. 31.
    Schrör K (1984) Prostaglandine und verwandte Verbindungen; Bildung, Funktion und pharmakologische Beeinflussung, Vol 2. Thieme, Stuttgart, p 138Google Scholar
  32. 32.
    Suzuki R, Pollard RB (1982) Mechanism for the suppression of gamma interferon responsiveness in mice after thermal injury. J Immunol 129: 1811–1816PubMedGoogle Scholar
  33. 33.
    Swain SL, Dennert G, Warner JF (1982) Culture supernatants of a stimulated T-cell line have helper activity that acts synergistically with interleukin-2 in the response of B-cells to antigen. Proc Natl Acad Sci USA 78: 2517CrossRefGoogle Scholar
  34. 34.
    Takatsu K, Tanaka K, Tominaga A et al. (1980) Antigen-induced T-cell replacing factor (TRF): III. Establishment of a T-cell hybrid clone continously producing TRF and functional analysis or released TRF. J Immunol 25: 2646Google Scholar
  35. 35.
    Trinchieri G, Perussia B (1985) Immune interferon: a pleiotropic lymphokine with multiple effects. Immunol Today 6: 131CrossRefGoogle Scholar
  36. 36.
    Twomey JJ (1982) Disorders of macrophages: excessive immunosuppression. In: Twomey J J (ed) The pathophysiology of human immunologic disorders. Urban and Schwarzenberg, Munich, pp 29–50, 125–147Google Scholar
  37. 37.
    Wood JJ, Rodrick ML, O’Mahony JB, Rodrick L et al. (1984) Inadequate interleukin 2 production: a fundamental immunological deficiency in patients with major burns. Ann Surg 200: 311–320PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag, Berlin Heidelberg 1989

Authors and Affiliations

  • E. Faist
  • W. Ertel
  • A. Mewes
  • S. Alkan
  • A. Walz
  • T. Strasser

There are no affiliations available

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