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Macrophage — T-Cell Interactions in Surgical Sepsis

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Immune Consequences of Trauma, Shock, and Sepsis

Abstract

As surgical and anesthetic management of patients with multiple injuries or those requiring major surgery have improved, the types of problems facing clinicians have changed. A chronicle of this evolution is provided by the various military conflicts in this century. In World Wars I and II, most deaths occurred due to irreversible hemorrhagic shock. In the Korean War, many casualties survived the initial period of shock but developed acute renal failure (ARF) with a mortality of 50% [1]. More rapid transport of injured patients, better management of shock, and the use of dialysis in Vietnam led to a lower incidence of ARF [2]. However, a new complication appeared in the form of adult respiratory distress syndrome (ARDS). Respiratory failure often occurred in patients without thoracic injuries and was associated with a mortality of 50%–60% [3]. Although early aggressive resuscitation of patients in shock and utilization of positive pressure ventilation have decreased the incidence of ARF and ARDS, the mortality for these complications has not changed appreciably in the last ten years [4].

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References

  1. Baxter CR, Zedlitz WH, Shires GT (1964) High output acute renal failure complicating traumatic injury. J Trauma 4: 567–572

    Article  PubMed  CAS  Google Scholar 

  2. Hardaway RM (1978) Vietnam wound analysis. J Trauma 18: 635–643

    Article  PubMed  Google Scholar 

  3. Blaisdell FW, Lewis FR Jr (1977) Recognition of the respiratory distress syndrome of shock and trauma: historical aspects. In: Blaisdell FW, Lewis FR Jr (eds) Respiratory distress syndrome of shock and trauma. Saunders, Philadelphia, pp 1–8

    Google Scholar 

  4. O’Mahoney JB, Palder S, Rodrick M et al. (1984) Depression of cellular immunity after multiple trauma in the absence of sepsis. J Trauma 24: 869–875

    Article  Google Scholar 

  5. Miller SE, Miller CL, Trunkey DD (1982) The immune consequences of trauma. Surg Clin North Am 62: 167–182

    PubMed  CAS  Google Scholar 

  6. Baker CC, Degutis LC, DeSantis JG, Baue AE (1985) The impact of a trauma service in a university hospital. Am J Surg 149: 453–458

    Article  PubMed  CAS  Google Scholar 

  7. Bendtzen K, Petersen J (1984) Role of interleukin-1 in antigen induced lymphokine production. Cell Immunol 83: 101–106

    Article  PubMed  CAS  Google Scholar 

  8. Dinarello CA (1984) Interleukin-1. Rev Infect Dis 6: 51–95

    Article  CAS  Google Scholar 

  9. Beller DI, Unanue ER (1982) Reciprocal regulation of macrophage and T cell function by way of soluble mediators. In: Pick E, Mizel S (eds) Lymphokines, vol 6, pp 25–36

    Google Scholar 

  10. Baker CC, Miller CL, Trunkey DD (1979) Identity of mononuclear cells which com-promise the resistance of trauma patients. J Surg Res 26: 478–4187

    Article  PubMed  CAS  Google Scholar 

  11. Antonacci AC, Calvano SE, Reaves LE, Prajapati A, Bockman R, Walte K, Mertelsman R, Gupta S, Good RA, Shires GT (1984) Autologous and allogeneic mixed lymphocyte responses following thermal injury in man: the immunomodulatory effects of Interleukin 1, Interleukin 2, and a prostaglandin inhibitor. Clin Immunol Immunopathol 30: 304–320

    Article  PubMed  CAS  Google Scholar 

  12. Kupper TS, Green DR, Chaudry IH et al. (1984) A cyclophosphamide sensitive sup-pressor T cell circuit induced by thermal injury. Surgery 95: 679–706

    Google Scholar 

  13. Wang BS, Heacock EH, Wu AVO, Mannick JA (1980) Generation of suppressor cells in mice after surgical trauma. J Clin Invest 66: 200–209

    Article  PubMed  CAS  Google Scholar 

  14. Hinshaw LB, Beller BK, Archer LT, Flourney DJ, White GL, Phillips RW (1974) Recovery from lethal Escherichia coli shock in dogs. Surg Gynecol Obstet 139: 851–856

    PubMed  CAS  Google Scholar 

  15. Hardaway RM III (1980) Endotoxemic shock. Dis Colon Rectum 24: 597–604

    Article  Google Scholar 

  16. Baker CC, Chaudry IH, Gaines HO, Baue AE (1983) Evaluation of factors affecting mortality following sepsis in a murine cecal ligation and puncture model. Surgery 94: 331–335

    PubMed  CAS  Google Scholar 

  17. Wichterman KA, Baue AE, Chaudry IH (1980) Sepsis and septic shock — a review of laboratory models and a proposal. J Surg Res 29: 189–201

    Article  PubMed  CAS  Google Scholar 

  18. MacLean RD, Mulligan WG, McLean APH, Duff JW (1967) Patterns of systemic shock in man — a detailed study of 56 patients. Ann Surg 166: 543–562

    Article  PubMed  CAS  Google Scholar 

  19. Baker CC, Kupper TS (1985) Clarification of the role of endotoxin in intra-abdominal and systemic sepsis. Surg Forum 36: 68–70

    Google Scholar 

  20. Baker CC, Yamada AH, Faist E, Kupper TS (1987) Interleukin-1 and T cell function following injury. J Burn Care Rehabil 8: 503–508

    PubMed  CAS  Google Scholar 

  21. Kaye J, Porcelli JT, Jones B, Janeway CA Jr (1983) Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cells can substitute for antigen and antigen presenting cells in the activation of T cells. J Exp Med 158: 836–856

    Article  PubMed  CAS  Google Scholar 

  22. Kaye J, Gillis S, Mizel SB, Shevark EM, Malek TR, Dinarello CA, Lachman LB, Janeway CA (1984) Growth of a cloned T cell line induced by monoclonal antibody specific for the antigen receptor: Interleukin 1 is required for the expression of receptors to In- terleukin 2. J Immunol 133: 1339–1345

    PubMed  CAS  Google Scholar 

  23. Alexander JW (1972) Host defense mechanisms against infection. Surg Clin North Am 52: 1367–1378

    PubMed  CAS  Google Scholar 

  24. Meakins JL et al. (1978) Delayed hypersensitivity and neutrophil Chemotaxis: effect of trauma. J Trauma 18: 240–247

    Article  PubMed  CAS  Google Scholar 

  25. Braley-Mullen H (1983) Activation of type III pneumococcal polysaccharide specific suppressor T cells in mice. J Immunol 131: 2190–2198

    PubMed  CAS  Google Scholar 

  26. Kupper TS, Baker CC, Ferguson TA, Green DR (1985) Burn induced Ly-2 suppressor T cell lower resistance to bacterial infection. J Surg Res 38: 606–612

    Article  PubMed  CAS  Google Scholar 

  27. Rosenstreich DL, Globe LM, Wahl LM et al. (1977) Analysis of the cellular defects of endotoxin-unresponsive C3H/HeJ mice. In: Schlessinger D (ed) Microbiology. American Society of Microbiology, Washington DC, pp 314–320

    Google Scholar 

  28. Faist E, Mewes A, Baker CC, Strasser T, Alkan SS, Rieber P, Heberer G (1987) Pros-taglandin E2 (PGE2) dependent suppression of IL-2 production in patients with major trauma. J Trauma 27: 837–848

    Article  PubMed  CAS  Google Scholar 

  29. Kupper TS, Green DR (1985) In vivo exposure to IL-1 or ETAF causes loss of antigen- presenting cell function. Br J Rheumatol 24 [Suppl 1]: 98–101

    Google Scholar 

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Authors
  1. C. C. Baker
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Editor information

Editors and Affiliations

  1. Dept. of Surgery, LM University Munich Klinikum Großhadern, Marchioninistr. 15, 8000, Munich 70, Germany

    Eugen Faist

  2. University of California, San Diego, California, 92103, USA

    John L. Ninnemann Ph. D. (Associate Adjunct Professor of Surgery) (Associate Adjunct Professor of Surgery)

  3. University of Alberta Edmonton, Alberta, T6G 2H7, Canada

    Douglas R. Green Ph. D. (Associate Professor of Immunology) (Associate Professor of Immunology)

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© 1989 Springer-Verlag, Berlin Heidelberg

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Baker, C.C. (1989). Macrophage — T-Cell Interactions in Surgical Sepsis. In: Faist, E., Ninnemann, J.L., Green, D.R. (eds) Immune Consequences of Trauma, Shock, and Sepsis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73468-7_7

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  • DOI: https://doi.org/10.1007/978-3-642-73468-7_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73470-0

  • Online ISBN: 978-3-642-73468-7

  • eBook Packages: Springer Book Archive

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