The Influence of Anesthetic Agents on the Immune Response: A Crucial Factor in Immune Suppression?
The immunological status, subsequent to surgery, plays a crucial part in the recovery of the patient. It is now entirely clear that immunological parameters are influenced by a multitude of factors induced by trauma or surgery. Neural and humoral factors are influenced by traumatic events and surgical operations resulting in the liberation of mediators. So far, in the event of trauma the situation is clear, but it is impossible to undertake surgical procedures without some type of anesthesia or analgesia. However, the anesthesia itself could exert an immune-depressive or immune-simulative influence or anesthesia might modify the surgical effects on the immunological state of the patient. The effect of anesthesia itself could again give rise to alterations in neurohumoral mechanisms, secondarily influencing immunologic parameters, or quite simply influence the immunological state by some direct action of the anesthetics on immunocompetent cells.
KeywordsNatural Killer Cell Anesthetic Agent Lymphocyte Proliferation Immunological State Serum Cortisol Level
Unable to display preview. Download preview PDF.
- 5.von Haefen B, Zenner HP (1987) Zum Einfluß verschiedener Anästhesieverfahren auf die Natürliche-Killer-Zell-Aktivität. Anaesthesist 36: Zentral Europäischer Anaesthesiekongreß, ZAK 87 München, p. 412Google Scholar
- 9.Park SK, Brody JJ, Wallace HA, Blakmore WS (1971) Immunosuppressive effect of surgery. Lancet 53: 108Google Scholar
- 12.Neuwelt EA, Kikuchi K, Hill SA, Lipsky P, Frenkel E (1982) Barbiturate inhibition of lymphocyte function. J Neurosurg 54: 254Google Scholar