Skip to main content
  • 67 Accesses

Abstract

Human skin is a complex organ composed of a stratified squamous epithelium (the epidermis), containing bone-marrow-derived and neural crest symbionts, which overlies a richly vascular matrix of connective tissue (dermis) and subcutaneous fat. The role of skin (and particularly the epidermis) in host defense has long been considered a passive one, and the production of keratins and lipids by the epidermal keratinocyte and of collagen and elastin by the dermal fibroblast were considered to be the most important functions of this organ.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Katz SI, Tamaki K, Sachs DH (1979) Epidermal Langerhans cells are derived from cells originating in bone marrow. Nature 282: 324

    Article  PubMed  CAS  Google Scholar 

  2. Kupper TS (1988) Interleukin 1 and other keratinocyte cytokines: functional and molecular characterization. Adv Dermatol 3: 293

    PubMed  CAS  Google Scholar 

  3. Kupper TS (1988) The role of epidermal cytokines. In: Shevach E, Oppenheim J (eds) The immunophysiology of cells and cytokines. Oxford University Press

    Google Scholar 

  4. Kupper TS, Ballard D, Chua AO et al. (1986) Human keratinocytes contain mRNA in-distinguishable from monocyte interleukin 1 mRNA. J Exp Med 164: 2095

    Article  PubMed  CAS  Google Scholar 

  5. Kupper TS, Dower S, Birchall N, Clark S, Lee F Interleukin 1 binds to specific receptors on human keratinocytes and induces granulocyte macrophage colony stimulating factor mRNA and protein: a potential autocrine role for IL-1 in epidermis (submitted for publication)

    Google Scholar 

  6. Kupper TS, Chua AO, Flood P, McGuire J, Gubler U (1987) Interleukin 1 gene expression in cultured human keratinocytes is augmented by ultraviolet irradiation. J Clin Invest 80: 430

    Article  PubMed  CAS  Google Scholar 

  7. Witmer-Pack M, Oliveier W, Valinsky J, Schuler G, Steinman R (1987) Granulocyte/ macrophage colony-stimulating factor is essential for the viability and function of cultured murine epidermal Langerhans cells. J Exp Med 166: 1484

    Article  PubMed  CAS  Google Scholar 

  8. Kupper TS, Mizutani H, Birchall N, May L, Sehgal P (1989) Beta 2 interferon/BSF-2/ interleukin 6 synergizes with interleukin 1 in the induction of T cell proliferation, (submitted for publication)

    Google Scholar 

  9. Stingl G, Koning F, Yamada H et al. (1987) Thy-1 + dendritic epidermal cells express T3 antigen and the T cell receptor gamma chain. Proc Natl Acad Sci USA 84: 4586

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag, Berlin Heidelberg

About this paper

Cite this paper

Kupper, T.S. (1989). Immunology of Skin. In: Faist, E., Ninnemann, J.L., Green, D.R. (eds) Immune Consequences of Trauma, Shock, and Sepsis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73468-7_43

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-73468-7_43

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73470-0

  • Online ISBN: 978-3-642-73468-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics