Suppression of Endotoxin-Induced Monokine Release by Human Serum Fractions

  • W. A. Flegel
  • H. Northoff
Conference paper


Minute amounts of endotoxin (lipopolysaccharide, LPS) will induce monocytes concomitantly to release interleukin 1 (IL1), tumor necrosis factor (TNF), and interleukin 6 (IL6). This mechanism was shown (Lehmann et al. 1987; Freudenberg et al. 1986) to be central in mediating the in vivo toxicity of LPS. Therefore, the mediator release by human monocytes upon stimulation with LPS is a suitable and sensitive in vitro model for investigating the toxic effects of LPS. Inhibition of LPS to induce mediator release in this in vitro model by different means might have implications for diminished in vivo toxicity of endotoxin.


Human Monocyte Mediator Release Lipoprotein Fraction Normal Human Serum Serum Fraction 
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Copyright information

© Springer-Verlag, Berlin Heidelberg 1989

Authors and Affiliations

  • W. A. Flegel
  • H. Northoff

There are no affiliations available

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