Abstract
Minute amounts of endotoxin (lipopolysaccharide, LPS) will induce monocytes concomitantly to release interleukin 1 (IL1), tumor necrosis factor (TNF), and interleukin 6 (IL6). This mechanism was shown (Lehmann et al. 1987; Freudenberg et al. 1986) to be central in mediating the in vivo toxicity of LPS. Therefore, the mediator release by human monocytes upon stimulation with LPS is a suitable and sensitive in vitro model for investigating the toxic effects of LPS. Inhibition of LPS to induce mediator release in this in vitro model by different means might have implications for diminished in vivo toxicity of endotoxin.
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© 1989 Springer-Verlag, Berlin Heidelberg
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Flegel, W.A., Northoff, H. (1989). Suppression of Endotoxin-Induced Monokine Release by Human Serum Fractions. In: Faist, E., Ninnemann, J.L., Green, D.R. (eds) Immune Consequences of Trauma, Shock, and Sepsis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73468-7_41
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DOI: https://doi.org/10.1007/978-3-642-73468-7_41
Publisher Name: Springer, Berlin, Heidelberg
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