Abstract
Platelet-activating factor (PAF) is a potent mediator of inflammatory processes produced by platelets, polymorphonuclear leukocytes, and macrophages (reviewed in [1, 2]). Several antagonists of PAF have been described [3], among which some are extracted from Ginkgo biloba leaves [4]. These substances, namely BN 52020, BN 52021, and 52022, inhibit PAF-induced platelet aggregation, the most potent one being BN 52021 (ginkgolide B) [5]. Stimulated macrophages released both PAF [2] and interleukin (IL)1 [6]. The involvement of IL1 in many aspects of the immune response suggests that this mediator is also an important regulatory molecule of the inflammatory reactions [6]. However, the possible link between the generation of PAF and IL1 has not yet been considered.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Braquet P, Touqui L, Shen TY, Vargaftig BB (1987) Perspectives in platelet-activating factor research. Pharmacol Rev 39: 97–145
Braquet P, Rola-Plesczcynski M (1979) The role of PAF in immunological responses. Immunol Today 9: 409
Braquet P, Godfroid JJ (1986) PAF specific binding sites: 2. Design of specific antagonists. Trends Pharmacol Sci 397
Braquet P (1985) Treatment or prevention of PAF disorders provoked by a new series of highly specific inhibitors. G.B. Patent. 84/18 424, 1984. BE 901, 915 (See CA 103:189808d)
Braquet P (1987) The ginkgolides: potent platelet-activating factor antagonists isolated from Ginkgo biloba L.: chemistry, pharmacology and clinical applications. Drugs Future 12: 643–699
Dinarello CA (1984) Interleukin-1 and the pathogenesis of the acute-phase response. N Engl J Med 311: 1413
Mizel SB, Oppenheim JJ, Rosenstreich DL (1978) Characterization of lymphocyte-activating factor (LAF) produced by a macrophage cell line, P 388 Dl. Biochemical char-acterization of LAF-induced by activated T cells and LPS. J Immunol 120: 1504
Gillis S, Ferm M, Ou W, Smith KA (1978) T cell growth factor: parameters of production and a quantitative microassay for activity. J Immunol 120: 2027
Barrett ML, Lewis GP, Ward S, Westwick J (1987) Platelet-activating factor induces interleukin 1 production from adherent macrophages. Br J Pharmacol 90: 113
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag, Berlin Heidelberg
About this paper
Cite this paper
Pignol, B., Henane, S., Mencia-Huerta, J.M., Braquet, P. (1989). Regulatory Role of Platelet-Activating Factor on Cytokine Production. In: Faist, E., Ninnemann, J.L., Green, D.R. (eds) Immune Consequences of Trauma, Shock, and Sepsis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73468-7_39
Download citation
DOI: https://doi.org/10.1007/978-3-642-73468-7_39
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-73470-0
Online ISBN: 978-3-642-73468-7
eBook Packages: Springer Book Archive