Abstract
Prostaglandins (PGs) and leukotriene’s (LTs) are products of arachidonic acid metabolism and are produced by many types of mammalian cells. These versatile compounds participate in a variety of normal physiological processes, including the maintenance of blood pressure and body temperature, protection of organs from damage caused by disease, and the regulation of parturition. It is now also clear that the PGs (particularly PGE2) and the LTs (particularly LTB4) are important in the normal regulation of the immune response. Conversely, shifts in the balance of arachidonic acid metabolite production have been implicated in shock, and a wide variety of disease states, including arthritis, malignancy, and the allergic disorders (reviewed by Ninnemann 1988).
Keywords
- Thermal Injury
- Human Peripheral Blood Mononuclear Cell
- Arachidonic Acid Metabolism
- Primary Human Peripheral Blood
- Normal Human Peripheral Blood Lymphocyte
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Anggard E, Arturson G, Jonsson CE (1970) Efflux of prostaglandins in lymph from scalded tissues. Acta Physiol Scand 80: 46A
Bach MK (1983) The leukotrienes; their structure, actions, and role in diseases. Current concepts series. Upjohn, Kalamazoo
Bankhurst AD, Hastain E, Goodwin JS, Peake GT (1981) The nature of the prostaglandin-producing mononuclear cell in human peripheral blood. J Lab Clin Med 97: 179–186
Bockman RS (1979) PGE inhibition of T lymphocyte colony formation. J Clin Invest 64: 812–821
Bonta IL, Parnham MJ (1982) Immunomodulatory-antiinflammatory functions of E-type prostaglandins. Minireview with emphasis on macrophage mediated effects. Int J Immunopharmacol 4: 103–109
Chouaib S, Chatenoud L, Klatzmann D, Fradelizi D (1984) The mechanism of inhibition of human IL-2 production. II. PGE2 induction of suppressor T lymphocytes. J Immunol 132: 1851–1857
Darrow TL, Tomar RH (1980) Prostaglandin-mediated regulation of the mixed lymphocyte culture and generation of cytotoxic cells. Cell Immunol 65: 172–178
Enteu U, Enre T, Cavdar AO, Turker RK (1980) An in vitro study on the effect of prostaglandin E2 and F2 alpha on E-rosette forming activity of normal lymphocytes. Prostaglandins Leukotrienes Med 5: 255–261
Faist E, Kupper TS, Baker CC, Chaudry IH, Dwyer J, Baue AE (1986) Depression of cellular immunity after major injury. Arch Surg 121: 1000–1005
Fischer A, Durandy A, Griscelli C (1981) Role of prostaglandin E2 in the induction of nonspecific T lymphocyte suppressor activity. J Immunol 126: 1452
Goldyne ME, Stobo JD (1979) Synthesis of prostaglandins by subpopulations of human peripheral blood monocytes. Prostaglandins 18: 687–695
Goodman MG, Weigle WO (1980) Modulation of lymphocyte activation. I. Inhibition by an oxidation product of arachidonic acid. J Immunol 125: 593–600
Goodwin JS, Messner RP, Peake GT (1978) Prostaglandin suppression of mitogen-stimulated lymphocytes in vitro. J Clin Invest 62: 753–760
Goodwin JS, Wiik A, Lewis M, Bankhurst AD, Williams RC (1979) High affinity binding sites for prostaglandin E on human lymphocytes. Cell Immunol 43: 150–159
Goodwin JS, Bromberg S, Staszak C, Kaszubowski PA, Messner RP, Neal JF (1981) Effect of physical stress on sensitivity of lymphocytes to inhibition by prostaglandin E2. J Immunol 127: 518–522
Gordon D, Bray M, Morley J (1976) Control of lymphokine secretion by prostaglandins. Nature 262: 401–407
Gorski A, Graciong Z, Dupont B (1982) Enhanced colonability of human T lymphocytes causes by their culturing in vitro. Immunology 44: 617–622
Grbic JT, Wood JJ, Jordan A, Rodrick ML, Mannick J A (1985) Lymphocytes from burned patients are more sensitive to suppression by prostaglandin E2. Surg Forum 108–110
Hamberg M, Jonsson CE (1973) Increased synthesis of prostaglandins in guinea pig following scalding injury. 87: 240
Hansbrough J, Petersonn V, Zapata-Sirvent R, Claman HN (1984) Postburn immunosuppression in an animal model. II. Restoration of cell-mediated immunity by immune-modulating drugs. Surgery 95: 290–295
Heggers JP, Loy GL, Robson MC, DelBeccaro EJ (1980) Histological demonstration of prostaglandins and thromboxanes in burned tissue. J Surg Res 28: 110–117
Humes JL, Bonney RW, Peius L, Dahlgren ME, Sadowski SS, Kuehl FA, Davies P (1977) Macrophages synthesize and release prostaglandins in response to inflammatory stimuli. Nature 269: 159
Kaszubowski PA, Goodwin JS (1982) Monocyte-produced prostaglandin induces Fc gamma receptor expression on human T cells. Cell Immunol 68: 343–348
Kennedy MS, Stobo JD, Goldyne ME (1980) In vitro synthesis of prostaglandins and related lipids by populations of human peripheral blood mononuclear cells. Prostaglandins 20: 135–145
Morley J, Bray MA, Jones RW, Nugteren DH, VanDorp DA (1979) Prostaglandins and thromboxanes production by human and guinea pig macrophages and leukocytes. Prostaglandins 17: 729–736
Neill MA, Henderson WR, Klebanoff SJ (1985) Oxidative degradation of leukotriene C4 by human monocytes and monocyte-derived macrophages. J Exp Med 162: 1634–1644
Ninnemann JL (1987) PGE regulates lymphocyte stimulation by I1–2. Proc Am Burn Assoc 19: 10
Ninnemann JL (1988) Prostaglandins, leukotrienes, and the immune response. Cambridge University Press, New York
Ninnemann JL, Stockland AE (1984) Participation of prostaglandin E in immunosuppression following thermal injury. J Trauma 24: 201–207
Oates JA, Roberts LD, Sweetman BJ, Maas RL, Gerkens JF, Tabber DF (1980) Metabolism of the prostaglandins and thromboxanes. Adv Prostaglandin Thromboxane Leukotriene Res 6: 35–41
Oropeza-Rendon RL, Bauer HC, Fischer H (1980) Effect of prostaglandin El on the level of cAMP in bone marrow macrophages. Inhibition of phagocytosis and cell shape changes. J Immunopharmacol 2: 133–147
Payan DG, Goetzl EJ (1983) Specific suppression of human T lymphocyte function by leukotriene B4. J Immunol 131: 551–553
Rappaport RS, Dodge GR (1982) Prostaglandin E inhibits the production of human interleukin 2. J Exp Med 155: 943–948
Rodrick ML, Saporoschetz IB, Wood JJ, Davis CF, Mannick JA (1985) Serum suppression of interleukin-2 (IL-2) production and IL-2 action in thermal injury. Surg Forum 98–99
Simkin NJ, Jelinek DF, Lipsky PE (1987) Inhibition of human B cell responsiveness by prostaglandin E2. J Immunol 138: 1074–1081
Teodorczyk-Injeyan J, Sparkes BG, Mills GB, Peters WJ, Falk RE (1986) Impairment of T cell activation in burn patients: a possible mechanism of thermal injury-induced immunosuppression. Clin Exp Immunol 65: 570–581
Teodorczyk-Injeyan JA, Sparkes BG, Peters WJ, Gerry K, Falls RE (1987) Prostaglandin E-related impaired expression of interleukin 2 receptor in the burn patient. Adv Prostaglandin Thromboxane Leukotriene Res 17: 151–154
VanEpps D (1981) Suppression of human lymphocyte migration by PGE2. Inflammation 5: 81–87
Williams JD, Czop JK, Austen KF (1984) Release of leukotrienes by human monocytes on stimulation of their phagocytic receptor for particulate activators. J Immunol 132: 3034–3040
Wood JJ, Rodrick ML, Grbic JT, Mannick JA (1986) Suppression of interleukin-2 (IL-2) production in an animal model of thermal injury is related to prostaglandin synthesis. Proc Surg Infect Soc: 33
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag, Berlin Heidelberg
About this paper
Cite this paper
Ninnemann, J.L. (1989). Prostaglandins and Leukotrienes in Monocyte/T Cell Function in Stress and Trauma. In: Faist, E., Ninnemann, J.L., Green, D.R. (eds) Immune Consequences of Trauma, Shock, and Sepsis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73468-7_35
Download citation
DOI: https://doi.org/10.1007/978-3-642-73468-7_35
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-73470-0
Online ISBN: 978-3-642-73468-7
eBook Packages: Springer Book Archive