Elastase from Polymorphonuclear Leukocytes, Complement, and C-Reactive Protein in Multiple Trauma Patients
The severity of injury in multiple trauma is classified as a rule according to anatomical injury patterns and pathological alterations of vital functions (Oestern et al. 1985). The immunological reactions to a severe mechanical trauma with extensive tissue and organ lesions have been inadequately investigated up to now. The objective of this study was to investigate the effects of mechanical trauma on defense mechanisms of the body in relation to the severity of injury. Nonspecific humoral and cellular defense mechanisms are more prominent compared with the specific immune response delay in time. Leukocyte immigration and phagocytosis, release of lysosomal enzymes, and mobilization of acute-phase proteins constitute so to speak the “first line of defense.”
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