Abstract
Complement is of importance for restricting microorganisms to their normal sites such as skin and gut as well as for clearing the blood stream of these invaders. During evolution organisms had complement for host defense before they were provided with antibodies (Muller-Eberhard 1975). This cascade system can be activated by an antibody fixed to an antigen but also in a more nonspecific way without antibodies. Chemotaxis, opsonization, and lysis of bacteria or injured or foreign cells are influenced by products formed when complement is activated, a process modulated by inhibitors. Hereditary defects leading to reduced amounts of complement from the alternative pathway are associated with repeated and sometimes life-threatening infections (Muller-Eberhard 1978). The same effect can be observed after extensive injuries leading to consumption of complement or after starvation or by prolonged medication with corticosteroids (Alexander et al. 1979; Alexander 1980; Atkinson et al. 1973).
Keywords
- Multisystem Organ Failure
- Extensive Injury
- Terminal Complement Complex
- Plasma Exchange Therapy
- Foreign Invader
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© 1989 Springer-Verlag, Berlin Heidelberg
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Heideman, M. (1989). The Role of Complement in Injury. In: Faist, E., Ninnemann, J.L., Green, D.R. (eds) Immune Consequences of Trauma, Shock, and Sepsis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73468-7_26
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DOI: https://doi.org/10.1007/978-3-642-73468-7_26
Publisher Name: Springer, Berlin, Heidelberg
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