Structure and Properties of a Novel Neutrophil-Activating Factor (NAF) Produced by Human Monocytes

  • A. Walz
  • P. Peveri
  • H. Aschauer
  • B. Dewald
  • M. Baggiolini
Conference paper


Neutrophils are the main cellular elements of antimicrobial defense and acute inflammation. Their activity depends largely on the release of cytotoxic, tissue-damaging, and cell-activating products. A variety of stimulatory molecules of different origin are known to condition neutrophil activity in inflamed tissues. Among the best-characterized ones are N-formyl-methionyl peptides (e.g., fMLP) related to bacterial products (Showell et al. 1976), C5a formed upon complement activation (Fernandez et al. 1978), and two lipids, platelet-activating factor (PAF) and leukotriene B4 (LTB4) (Dewald and Baggiolini 1986), which are released by stimulated phagocytes (Baggiolini et al. 1988). At sites of chronic inflammation, neutrophils are exposed to the products of activated mononuclear phagocytes which are prominent in such lesions. We have studied the production of neutrophil-activating factors by human monocytes stimulated in different ways, and describe here one of these factors, termed NAF, which binds to human neutrophils via a selective surface receptor and acts like the chemotactic agonists C5a and fMLP.


Human Neutrophil Mononuclear Phagocyte Chemotactic Factor Peptide Agonist Human Alveolar Macrophage 
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Copyright information

© Springer-Verlag, Berlin Heidelberg 1989

Authors and Affiliations

  • A. Walz
  • P. Peveri
  • H. Aschauer
  • B. Dewald
  • M. Baggiolini

There are no affiliations available

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