Abstract
Alteration in monocyte/macrophage (MØ) functions post-trauma increasingly appears to be related to the development of post-trauma immunoincompetence and metabolic derangement [1–11]. These inimical post-trauma alterations in monocytes can be categorized into three types: (1) depression in antigen-presenting function due to alterations in antigen processing or presentation, (2) alterations in monokine secretion, and (3) stimulation of inhibitory MØ factor production. Our hypothesis is that a post-trauma shift in the ratio of MØ subsets may be causal in all three of these types of monocyte defects.
This study was supported by grants GM36214 and DAMD 17-86-C-6091 from the U.S. Public Health Service.
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References
Stratta R, Warden G, Ninnemann J et al. (1986) Immunologic parameters in burned patients: effect of therapeutic interventions. J Trauma 26: 7
Alexander J (1980) The role of host defense mechanisms in surgical infections. Surg Clin North Am 60: 107
Hansbrough J, Zapata-Sirvent R, Peterson V (1987) Immunomodulation following burn injury. Surg Clin North Am 67: 69
Baker C, Yamada A, Faist E et al. (1987) Interleukin-1 and T cell function following injury. JBCR 8: 503
Faist E, Kupper T, Baker C et al. (1986) Depression of cellular immunity after major injury. Arch Surg 121: 1000
Watters J, Bessey P, Dinarello C et al. (1986) Both inflammatory and endocrine mediators stimulate host responses to sepsis. Arch Surg 121: 179
Deitch E, Bridges R, Dobke M et al. (1987) Burn wound sepsis may be promoted by a failure of local antibacterial host defenses. Ann Surg 206: 340
Carrico J, Meakins J, Marshall J et al. (1986) Multiple-organ-failure syndrome. Arch Surg 121: 196
Weinstein J, Taylor J (1987) Interleukin-1 and the acute-phase response: induction of mouse liver serum amyloid A mRNA by murine recombinant interleukin-1. J Trauma 27: 1227
Warren R, Starnes F, Gabrilove J et al. (1987) The acute metabolic effects of tumor necrosis factor administration in humans. Arch Surg 122: 1396
Moran K, Munster A (1987) Alterations of the host defense mechanism in burned patients. Surg Clin North Am 67: 47
Hoyt D, Ozkan A, Ninnemann J (1987) Immunologic monitoring of infection risk in trauma patients: research questions and an approach to the problem. JBCR 8: 549
Unanue E, Beller D, Lu C et al. (1984) Antigen presentation: comments on its regulation and mechanism. J Immunol 132: 1
Ziegler H, Orlin C, Cluff C (1987) Differential requirements for the processing and presentation of soluble and particulate bacterial antigens by macrophages. Eur J Immunol 17: 1287
Kaye J, Gillis S, Mizel S et al. (1984) Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor: interleukin 1 is required for the expression of receptors for interleukin 2. J Immunol 133: 1339
Kurt-Jones EA, Hamberge S, Ohara J et al. (1987) Heterogeneity of helper/inducer T lymphocytes. J Exp Med 166: 1774
Kupper T, Horowitz M, Lee F (1987) Autocrine growth of T cells independent of IL-2: identification of interleukin 4 (IL-4, BSF-1) as an autocrine growth factor for a cloned antigen-specific helper T cell. J Immunol 138: 4280
Kilian L, MacDonald G, West J et al. (1987) Cloned, la-restricted T cells that do not produce interleukin 4 (IL-4) B cell stimulatory factor 1 (BSF-1) fail to keep antigen spe-cific B cells. J Immunol 138: 1674
Morimoto C, Letvin NL, Boyd AW et al. (1985) The isolation and characterization of the human helper inducer T cell subset. J Immunol 134: 3762
Van Damme J, Opdenakker G, Simpson RJ et al. (1987) Identification of the human 26 kD protein, interferon β2 (IFN-β2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor. J Exp Med 165: 914
Taga T, Kawanishi Y, Hardy R et al. (1987) Receptors for B cell stimulatory factor 2. J Exp Med 166: 967
Aarden LA, De Groot ER, Schaap OL et al. (1987) Production of hybridoma growth factor by human monocytes. Eur J Immunol 17: 1411
Yasukawa K, Hirano T, Watanabe Y et al. (1987) Structure and expression of human B cell stimulatory factor-2 (BSF-2I, L-6) gene. EMBO 6: 2939
Miller C, Claudy B (1979) Suppressor T cells induced by thermal injury. Cell Immunol 44: 201
Kupper T, Baker C, Ferguson T et al. (1985) A burn induced Ly-2 suppressor T cell lowers resistance to bacterial infection. J Surg Res 38: 606
Gibbons R, Martinez O, Horn J (1988) Early alterations in HLA class II antigen expression and response to tetanus toxoid by peripheral blood mononuclear cells from patients with severe injury or burns. Abstracts OR3. 1st International Congress on the Immune Consequences of Trauma, Shock and Sepsis. Mechanisms and therapeutic approaches. Munich, March 3–5, 1988
Zembala M, Uracz W, Ruggiero I et al. (1984) Isolation and functional characteristics of FcR+ and FcR- human monocyte subsets. J Immunol 133: 1293
Ohkawa S, Martin L, Fukunishi Y et al. (1987) Regulatory role of FcR+ and FcR- monocyte subsets in Mycobacterium leprae-induced lymphoproliferative response in vitro. Clin Exp Immunol 67: 43
Pryjma J, Flad H, Gruber M et al. (1986) Monocyte-T-cell interactions in the regulation of polyclonal B-cell response. Scand J Immunol 24: 21
Looney R, Abraham G, Anderson C (1986) Human monocytes and U937 cells bear two distinct Fc receptors for IgG1. J Immunol 136: 1641
Rodrick M, Wood J, Grbic J et al. (1986) Defective IL-2 production in patients with severe burns and sepsis. Lymphokine Res 5: S75
Faist E, Mewes A, Baker C et al. (1987) Prostaglandin E2 (PGE2)-dependent suppression of interleukin α (IL-2) production in patients with major trauma. J Trauma 27: 837
Nijsten M, DeGroot E, TenDuis H et al. (1987) Serum levels of interleukin-6 and acute phase responses. Lancet 11: 921
Takai Y, Wong G, Clark S et al. (1988) B cell stimulatory factor-2 is involved in the differentiation of cytotoxic T lymphocytes. J Immunol 140: 508
Zucali J, Elfenbein G, Barth K et al. (1987) Effects of human interleukin 1 and human tumor necrosis factor on human T lymphocyte colony formation. J Clin Invest 80: 772
Helfgor D, May A, Sthoeger Z et al. (1987) Bacterial lipopolysaccharide (endotoxin) enhances expression and secretion of β2 interferon by human fibroblasts. J Exp Med 166: 1300
Garman R, Jacobs K, Clark S et al. (1987) B-cell-stimulatory factor 2 (β 2 interferon) functions as a second signal for interleukin 2 production by mature murine T cells. Proc Natl Acad Sci USA 84: 7629
Le J, Vilcek J (1987) Tumor necrosis factor and interleukin 1: cytokines with multiple overlapping biological activities. Lab Invest 56: 234
Dinarello C, Cannon J, Wolff S et al. (1986) Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1. J Exp Med 163: 1433
Damas P, Gysen P, Lopez M et al. (1988) Cachectin (TNFα) serum level in human during septic shock. 1st International Congress on the Immune Consequences of Trauma, Shock and Sepsis. Mechanisms and therapeutic approaches. Munich, March 3–5, 1988
March CJ, Mosley B, Larsen A et al. (1985) Cloning, sequence and expression of two distinct human interleukin-1 complimentary DNAs. Nature 315: 641
Demuczuk S, Baumberger C, Mach B et al. (1987) Expression of human IL 1α and β messenger RNAs and IL 1 activity in human peripheral blood mononuclear cells. J Mol Cell Immunol 3: 255
Kurt-Jones EA, Beller D, Mizel S et al. (1985) Identification of a membrane-associated interleukin 1 in macrophages. Proc Natl Acad Sci USA 82: 1204
Conlon PJ, Grabstein KH, Alpert A et al. (1987) Localization of human mononuclear cell interleukin 1. J Immunol 139: 98
Bendtzen K, Mandrup-Poulsen T, Nerup J (1986) Cytotoxicity of human pI7 interleukin-1 for pancreatic islets of Langerhans. Science 232: 1545
Matsushima K, Taguchi M, Kovacs E et al. (1986) Intracellular localization of human monocyte associated interleukin 1 (IL1) activity and release of biologically active IL 1 from monocytes by trypsin and plasmin. J Immunol 136: 2883
Auron P, Warner S, Webb A et al. (1987) Studies on the molecular nature of human interleukin 1. J Immunol 138: 1447
Miller CL, Graziano CJ, Lim RC (1982) Human monocyte plasminogen activator production: correlation to altered MØ-T lymphocyte intersection
Cerami A, Beutler B (1988) The role of cachectin/TNF in endotoxic shock and cachexia. Immunol Today 9: 28
Beutler B, Cerami A (1987) Cachectin: more than a tumor necrosis factor. N Engl J Med 316: 379
Tracey K, Lowry S, Fahey T et al. (1987) Cachectin/tumor necrosis factor induces lethal shock and stress hormone responses in the dog. Surg Gynecol Obstet 164: 415
Ruddle N (1987) Tumor necrosis factor and related cytotoxins. Immunol Today 8: 129
Beutler B, Tbacenko V, Mibserk J et al. (1986) Effect of gamma interferon on cachectin expression by mononuclear phagocyte. J Exp Med 164: 1791 - 1796
Hoffman M, Weinberg JB (1987) Tumor necrosis factor-α (TNF) stimulates peroxide production and expression of Fc receptors for IgG2b/Ia (FcR), but does not induce la expression on murine peritoneal macrophages ( M.P. ). J Leukocyte Biol 5: 609
Dayer J, Beutler B, Cerami A (1985) Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts. J Exp Med 162: 2163
Le J, Weinstein D, Gubler U et al. (1987) Induction of membrane-associated interleukin 1 by tumor necrosis factor in human fibroblasts. J Immunol 138: 2137
Tripp C, Wyche A, Unanue E et al. (1986) The functional significance of the regulation of macrophage la expression by endogenous arachidonate metabolites in vitro. J Immunol 137: 3915
Wood J, Grbic J, Rodrick M et al. (1987) Suppression of interleukin 2 production in an animal model of thermal injury is related to prostaglandin synthesis. Arch Surg 122: 179
Suzuki F, Pollard RB (1987) Suppressor cells generated in mice late after thermal injury. J Trauma 27: 379
Green DR, Wang N, Zheng H (1987) A suppressor-inducer factor produced by burn trauma-associated T cells. JBCR 8: 521
Miller-Graziano C, Fink M, Wu J et al. (1988) Mechanisms of altered monocyte prostaglandin E2 production in severely injured patients. Arch Surg 123: 293
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Miller-Graziano, C.L., Szabo, G., Takayama, T., Wu, Jy. (1989). Alterations of Monocyte Function Following Major Injury. In: Faist, E., Ninnemann, J.L., Green, D.R. (eds) Immune Consequences of Trauma, Shock, and Sepsis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73468-7_10
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DOI: https://doi.org/10.1007/978-3-642-73468-7_10
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