The Immune Consequences of Trauma: An Overview

  • J. L. Ninnemann


Trauma, considered as a whole, remains the greatest single killer of the US adult population. A significant component of mortality after injury is due to an induced immunological deficiency, a defect responsible for septic death. While discussion of immune deficiency states usually brings to mind AIDS, or well defined congenital diseases, there has been increasing interest in and concern for immunological depression acquired as a result of accidental or operative injury in an otherwise normal host. An excellent recent sampling of the literature, for example, can be found in the November/December 1987 issue of the Journal of Burn Care and Rehabilitation, which contains papers from a recent conference on the subject. The material for this review, in fact, is taken from one of the papers in this volume (Ninnemann 1987). In the case of major injuries, immunological changes can be precipitous and leave the host vulnerable to life-threatening sepsis. Fortunately, however, injury induced immune depression is completely reversible, and with an understanding of its causes has come the hope of controlling immunity in favor of the host.


Lymphocyte Response Immune Consequence Immunological Change Multiple Trauma Patient Skin Test Reactivity 
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© Springer-Verlag, Berlin Heidelberg 1989

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  • J. L. Ninnemann

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