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Arteriosklerose, die Entwicklung und Pathogenese vom Gesichtspunkt des Morphologen aus

  • Conference paper
45 Jahre Herzinfarkt- und Fettstoffwechselforschung

Zusammenfassung

Die morphologische Arterioskleroseforschung hat schon im vergangenen Jahrhundert begonnen. Die Morphologie hat sehr genau die Veränderungen und die verschiedenen Formen der Arteriosklerose beschrieben. Diese morphologischen Befunde hatten aber die initiale Phase der Atherosklerose nicht beschrieben, da diese als Resultat erst nach einer langen Lebenszeit erscheint. In den ersten Befunden wurden schon ätiologische Vorschläge gemacht. So hat Virchow (1856) zum ersten Mal die Entzündung der Arterien und ihre Degeneration beschrieben, die dann dem Morphologen als arteriosklerotische Veränderung erscheinen. Rokitansky (1852) hat die Thrombentheorie in den Vordergrund gestellt und hatte die Vorstellung, daß sich Thromben an der Oberfläche der Arterien bilden und die Organisation dieser führt dann zu skierotischen Läsionen. Marchand (1904) hat darüber berichtet, daß die Gefäße in der Adventitia für die arteriosklerotischen Läsionen verantwortlich sind, da sich die ersten Veränderungen in den kleinen Vasa vasorum abspielen und deren Verschluß zu sekundären Veränderungen in der Wand der Arterien führt, welche in einer Degeneration und Proliferation zum Ausdruck kommen. Der Plasmadurchfluß durch die Wand der Arterien wurde schon früher diskutiert (Schürmann u. MacMahon 1933; Doerr 1963). Auch die Endothelschädigung wurde mehrfach untersucht (Clowes et al. 1986; Harlan et al. 1985; Reidy 1983; Reidy u. Schwartz 1985).

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Authors
  1. H. Jellinek
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  2. É. Takács
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Editors and Affiliations

  1. Medizinischen Klinik Diakonissenkrankenhaus Mannheim, Akademisches Lehrkrankenhaus der Universität Heidelberg, Speyerer Straße 91-93, 6800, Mannheim, Germany

    Hubert Mörl (Chefarzt) (Chefarzt)

  2. Med. Univ. Klinik, Bergheimer Straße 58, 6900, Heidelberg, Germany

    Curt Diehm (Oberarzt) (Oberarzt)

  3. Dr. Karl Thomae GmbH, Birkendorfer Straße 65, 7950, Biberach/Riß, Germany

    Gerhard Heusel

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© 1988 Springer-Verlag Berlin Heidelberg

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Jellinek, H., Takács, É. (1988). Arteriosklerose, die Entwicklung und Pathogenese vom Gesichtspunkt des Morphologen aus. In: Mörl, H., Diehm, C., Heusel, G. (eds) 45 Jahre Herzinfarkt- und Fettstoffwechselforschung. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73440-3_7

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  • DOI: https://doi.org/10.1007/978-3-642-73440-3_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-18945-9

  • Online ISBN: 978-3-642-73440-3

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