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Endogenous Opioids in the Dorsal Vagal Complex and Resting Cardiovascular Function in the Anesthetized Rat

  • A. H. Hassen
  • E. P. Broudy
Conference paper

Abstract

Opioid peptides and opioid agonists elicit cardiovascular responses which are dependent upon the site of action and receptor specificity. For example, in the rat selective mu-agonists increased mean arterial pressure (MAP) following injection into the nucleus of tractus solitarius (NTS) or dorsal motor nucleus of the vagus (DMV). However, heart rate (HR) was increased following injection into the NTS but unchanged following injection into the DMV [3,4]. In contrast, kappa-agonists did not elicit consistent changes in MAP or HR following injection into the NTS, but did decrease HR and MAP following injection into the DMV [3,5]. Opioid peptides have also been shown to elicit specific pressor or depressor actions following injection into the NTS and these responses appear to be a function of relative receptor selectivity [10,11].

Keywords

Mean Arterial Pressure Opioid Receptor Cardiovascular Response Opioid Peptide Endogenous Opioid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • A. H. Hassen
    • 1
  • E. P. Broudy
    • 1
  1. 1.Department of PhysiologyWest Virginia School of Osteopathic MedicineLewisburgUSA

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