Abstract
Opioid peptides and opioid agonists elicit cardiovascular responses which are dependent upon the site of action and receptor specificity. For example, in the rat selective mu-agonists increased mean arterial pressure (MAP) following injection into the nucleus of tractus solitarius (NTS) or dorsal motor nucleus of the vagus (DMV). However, heart rate (HR) was increased following injection into the NTS but unchanged following injection into the DMV [3,4]. In contrast, kappa-agonists did not elicit consistent changes in MAP or HR following injection into the NTS, but did decrease HR and MAP following injection into the DMV [3,5]. Opioid peptides have also been shown to elicit specific pressor or depressor actions following injection into the NTS and these responses appear to be a function of relative receptor selectivity [10,11].
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© 1988 Springer-Verlag Berlin Heidelberg
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Hassen, A.H., Broudy, E.P. (1988). Endogenous Opioids in the Dorsal Vagal Complex and Resting Cardiovascular Function in the Anesthetized Rat. In: Stumpe, K.O., Kraft, K., Faden, A.I. (eds) Opioid Peptides and Blood Pressure Control. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73429-8_9
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DOI: https://doi.org/10.1007/978-3-642-73429-8_9
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-18935-0
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