Endogenous Opioids in the Dorsal Vagal Complex and Resting Cardiovascular Function in the Anesthetized Rat

  • A. H. Hassen
  • E. P. Broudy
Conference paper


Opioid peptides and opioid agonists elicit cardiovascular responses which are dependent upon the site of action and receptor specificity. For example, in the rat selective mu-agonists increased mean arterial pressure (MAP) following injection into the nucleus of tractus solitarius (NTS) or dorsal motor nucleus of the vagus (DMV). However, heart rate (HR) was increased following injection into the NTS but unchanged following injection into the DMV [3,4]. In contrast, kappa-agonists did not elicit consistent changes in MAP or HR following injection into the NTS, but did decrease HR and MAP following injection into the DMV [3,5]. Opioid peptides have also been shown to elicit specific pressor or depressor actions following injection into the NTS and these responses appear to be a function of relative receptor selectivity [10,11].


Mean Arterial Pressure Opioid Receptor Cardiovascular Response Opioid Peptide Endogenous Opioid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Dashwood MR, Feldberg W (1980) Release of opioid peptides in anesthetized cats. Br J Pharmacol 68: 697–703PubMedGoogle Scholar
  2. 2.
    Farsang C, Kunos G (1979) Naloxone reverses the antihypertensive effect of clonidine. Br J Pharmacol 67: 161–164PubMedGoogle Scholar
  3. 3.
    Hassen AH (1985) Dorsal motor nucleus of the vagus: selective mu- and kappa-opioid receptor mediated cardiovascular responses. Soc Neurosic Abstr 11: 191Google Scholar
  4. 4.
    Hassen AH, Feuerstein G, Faden AI (1982) μ Receptors and opioid cardiovascular effects in the NTS of rat. Peptides 3: 1031–1037PubMedCrossRefGoogle Scholar
  5. 5.
    Hassen AH, Feuerstein G, Faden AI (1984) Kappa opioid receptors modulate cardiorespiratory function in midbrain nuclei of rat. J Neuroscience 4: 2213–2221Google Scholar
  6. 6.
    Leslie RA (1985) Neuroactive substances in the Dorsal Vagal Complex of the medulla oblongata: nucleus of the tractus solitarius, area postrema and dorsal motor nucleus of the vagus. Neurochem Int 7: 191–211PubMedCrossRefGoogle Scholar
  7. 7.
    Montastruc JL, Montastruc P, Morales-Olivas F (1981) Potentiation by naloxone of pressor reflexes. Br J Pharmacol 74: 105–109PubMedGoogle Scholar
  8. 8.
    Paterson SJ, Robson LE, Kosterlitz HW (1983) Classification of opioid receptors. Br Med Bull 39: 31–36PubMedGoogle Scholar
  9. 9.
    Paxinos G, Watson C (1982) The rat brain in stereotaxic coordinates. Academic, New YorkGoogle Scholar
  10. 10.
    Petty MA, De Jong W (1982) Cardiovascular effects of (βendorphin after microinjection into the nucleus tractus solitarii of the anesthetized rat. Eur J Pharmacol 81: 449–457PubMedCrossRefGoogle Scholar
  11. 11.
    Petty MA, De Jong W (1983) Enkephalins induce a centrally mediated rise in blood pressure in rats. Brain Res 260: 322 - 325PubMedCrossRefGoogle Scholar
  12. 12.
    Quock RM, Kouchich FJ, Vaughn LK, Fries DS (1985) Narcotic antagonists-induced hypotension on the spontaneously hypertensive rat. Life Sci 37: 819–826PubMedCrossRefGoogle Scholar
  13. 13.
    Zajac JM, Gacel G, Petit F, Dodey P, Rossignol P, Roques BP (1983) Delta-kephalin, Tyr-D- Thr-Gly-Phe-Leu-Thr: a new highly potent and fully specific agonists for opiate 6 receptors. Biochem Biophys Res Commun 111: 390–397PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • A. H. Hassen
    • 1
  • E. P. Broudy
    • 1
  1. 1.Department of PhysiologyWest Virginia School of Osteopathic MedicineLewisburgUSA

Personalised recommendations