Effects of Hemorrhagic Shock on Plasma Met-enkephalin, Vasopressin, Catecholamines, and Cardiovascular Functions in Intact and Adrenalectomized Dogs
It is well known that enkephalins in the brain, unlike the adrenal gland and sympathetic nervous system, coexist with vasopressinergic neurons in the hypothalamoneuro- hypophyseal system (Martin and Voigt 1981; Martin et al. 1983). Moreover, the enkephalin contents of this region have been reported to decrease in dehydrated rats and/or Brattleboro rats with a genetic defect in vasopressin synthesis (Marina et al. 1977; Rossier et al. 1979). Furthermore, it has recently been documented that plasma enkephalin-like immunoreactivity is increased in animals with endotoxic or hemorrhagic shock (Evans et al. 1984; Lang et al. 1982), reminiscent of vasopressin release in hypotensive shock (Share 1974).
KeywordsCentral Venous Pressure Hemorrhagic Shock Mean Arterial Blood Pressure Plasma Osmolality Hemorrhagic Hypotension
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