Effect of Opiate Receptor Blockade on the Cardiovascular and Plasma Noradrenaline Response to Intravenous Tyramine in Man

  • P. M. G. Bouloux
  • A. Grossman
  • G. M. Besser
Conference paper


There is now abundant evidence to support the contention that endogenous opioids peptides play an important role in the regulation of the mammalian cardiovascular system (Holaday 1983; Rubin 1984). Opioids modulate baroreflex sensitivity in man (Rubin 1984) and regulate blood pressure during sleep (Rubin et al. 1981). They have also recently been shown to inhibit the sympathomedullary response to isometric exercise, a cold pressor test, acute exercise, and insulin-induced hypoglycemia in man (Grossman et al. 1984; Bouloux et al. 1985 a, b; Lam et al. 1986).


Adrenal Medulla Opioid Peptide Acute Exercise Cold Pressor Test Adrenal Chromaffin Cell 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • P. M. G. Bouloux
    • 1
  • A. Grossman
    • 1
  • G. M. Besser
    • 1
  1. 1.Department of EndocrinologySt. Bartholomews HospitalLondonUK

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