Opioid Peptides in Human Adrenal Medulla: Their Role in the Modulation of Catecholamine Secretion
Large amounts of opioid peptides (OPs), particularly those deriving from proenkephalin A, have been demonstrated in adrenal medulla of several animal species (for review see Livett 1984) and in human pheochromocytoma tissue (Sullivan et al. 1978; Giraud et al. 1982; Yoshimasa et al. 1984). Their functional role in adrenal medulla or human pheochromocytoma is still unknown, although evidence is emerging that they might modulate some adrenomedullary functions such as the release of catecholamines (CAs) (Costa et al. 1981; Saiani and Guidotti 1982; Mannelli et al. 1983; Mannelli et al. 1984; Bouloux et al. 1984).
KeywordsChromaffin Cell Adrenal Medulla Opioid Peptide Peripheral Plasma Naloxone Administration
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