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Role of Tumour Cell Eicosanoids and Membrane Glycoproteins IRGPIb and IRGPIIb/IIIa in Metastasis

  • Chapter
Eicosanoids, Lipid Peroxidation and Cancer

Abstract

Eicosanoids are a group of oxygenated arachidonic acid metabolites which include Prostaglandins, thromboxanes, leukotrienes, lipoxins, and various hydroperoxy and hydroxy fatty acids. Eicosanoids are implicated in diverse cellular functions such as Chemotaxis, proliferation, cell-cell signaling etc. The first committed step in the biosynthesis of each of the eicosanoids, the incorporation of molecular oxygen into polyunsaturated fatty acids, is catalyzed by one of a group of enzymes calles fatty acid oxygenases. This group includes the cyclooxygenase (COX) of Prostaglandin endoperoxide synthase (PGH) and various lipoxygenases (LOX).

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Authors and Affiliations

  1. Gershenson Radiation Oncology Center, Harper Grace Hospitals, Detroit, Michigan, 48 202, USA

    K. V. Honn, I. M. Grossi, H. Chopra, B. W. Steinert, J. M. Onoda, K. K. Nelson & J. D. Taylor

  2. Departments of Radiation Oncology and Biological Sciences, Wayne State University, USA

    K. V. Honn, I. M. Grossi, H. Chopra, B. W. Steinert, J. M. Onoda, K. K. Nelson & J. D. Taylor

Authors
  1. K. V. Honn
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  2. I. M. Grossi
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  3. H. Chopra
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  4. B. W. Steinert
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  5. J. M. Onoda
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  6. K. K. Nelson
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  7. J. D. Taylor
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Editor information

Editors and Affiliations

  1. Frauenklinik, Universitäts-Klinikum Steglitz, Hindenburgdamm 30, 1000, Berlin 45, Germany

    Santosh K. Nigam Ph.D., M.B., B.Ch.

  2. Department of Biology and Biochemistry, Brunel University, Uxbridge, Middlesex, UB8 3PH, UK

    David C. H. McBrien Ph.D.  & Trevor F. Slater Ph.D., D.Sc., M.D.(Hon.)  & 

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© 1988 Springer-Verlag Berlin Heidelberg

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Honn, K.V. et al. (1988). Role of Tumour Cell Eicosanoids and Membrane Glycoproteins IRGPIb and IRGPIIb/IIIa in Metastasis. In: Nigam, S.K., McBrien, D.C.H., Slater, T.F. (eds) Eicosanoids, Lipid Peroxidation and Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73424-3_4

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  • DOI: https://doi.org/10.1007/978-3-642-73424-3_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-18932-9

  • Online ISBN: 978-3-642-73424-3

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