Intratumoral Fibrin Stabilization
Fibrin deposition in the interstitial space of the stroma of malignant tumours is a frequent finding (see reviews by Rickles and Edwards 1983; Dvorak et al. 1983) and can be regularly observed, among others, in lymph nodes with Hodgkin’s disease (Harris et al. 1982). Hypotheses based on supporting experimental and clinical data implicate intratumoral fibrin in the promotion of tumour growth and metastasis formation (Laki 1974; Dvorak et al. 1983). Fibrin may serve as a barrier making tumour cells relatively inaccessible for the host’s immune response, may play an important role in tumour angiogenesis and desmoplasia and might support the implantation of tumour cells at metastatic sites.
KeywordsUrea Adenocarcinoma Heparin Oncol Polypeptide
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- Ádány R, Kappelmayer J, Muszbek L (1987b) Expression of FXIII subunit a in different types of human macrophages. In: Mauri C, Rizzo SC, Ricevuti G (eds) The biology of phagocytes in health and disease, Pergamon, OxfordGoogle Scholar
- Ádány R, Glukhova MA, Kabakov AY, Muszbek L (1988) Characterization of human connective tissue cells containing factor XIII subunit a. J Clin Pathol, (in press)Google Scholar
- Kasai S, Kunimoto T, Nitta K (1983) Cross-linking of fibrin by activated factor XIII stimulates attachment, morphological changes and proliferation of fibroblasts. Biomed Res 4:155–160Google Scholar
- Muszbek L, Laki K (1984) Interaction of thrombin with proteins other than fibrinogen (thrombin susceptible bonds). Activation of FXIII. In: Machovich R (ed) The thrombin. CRC, Boca Raton, pp 321–342Google Scholar
- Ueyama M, Urayama T (1977) The role of factor XIII in fibroblast proliferation. Jpn J Exp Med 48:135–142Google Scholar
- VanDeWater L, Tracy PB, Aronson D, Mann KG, Dvorak HF (1985) Tumor cell generation of thrombin via prothrombinase assembly. Cancer Res 45:5521–5525Google Scholar