Ethane and n-Pentane Formation in a Reconstituted Microsomal Lipid Peroxidation System
Carcinogenesis has been related to lipid peroxidation (McBrien and Slater 1982), because some reaction products formed have DNA damaging (Ueda et al. 1985; Brambilla et al. 1986; Winter et al. 1986), mutagenic (Cajelli et al. 1987) or tumour promoting (Cerutti 1985; Kensler and Taffe 1986) activities. For example, the carcinogenic effects of the non-genotoxic peroxisome proliferators have been related to lipid peroxidation induced by increased peroxisome H2O2 formation (Reddy et al. 1982; Goel et al. 1986). Since after treatment with such compounds hydroxyl radicals are formed in peroxisomes in vivo (Elliott et al. 1986) it is suggested that DNA damage occurs indrectly by lipid peroxidation products.
KeywordsAlkane NADPH Hydroperoxide Catechol Tetrachloride
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