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Ethane and n-Pentane Formation in a Reconstituted Microsomal Lipid Peroxidation System

  • H. Kappus
  • J. Kostrucha

Abstract

Carcinogenesis has been related to lipid peroxidation (McBrien and Slater 1982), because some reaction products formed have DNA damaging (Ueda et al. 1985; Brambilla et al. 1986; Winter et al. 1986), mutagenic (Cajelli et al. 1987) or tumour promoting (Cerutti 1985; Kensler and Taffe 1986) activities. For example, the carcinogenic effects of the non-genotoxic peroxisome proliferators have been related to lipid peroxidation induced by increased peroxisome H2O2 formation (Reddy et al. 1982; Goel et al. 1986). Since after treatment with such compounds hydroxyl radicals are formed in peroxisomes in vivo (Elliott et al. 1986) it is suggested that DNA damage occurs indrectly by lipid peroxidation products.

Keywords

Lipid Peroxidation Lipid Peroxidation Product Free Radic Biol High Oxygen Concentration Lipid Peroxidation Process 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • H. Kappus
    • 1
  • J. Kostrucha
    • 1
  1. 1.Free University of BerlinBerlin 65Germany

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