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Detection of Containment Breach in Bioprocess Plant using Aeorobiological Monitors

  • I. W. Stewart
  • G. Leaver
Conference paper

Summary

This paper describes the progress made on the UK part of this joint project on the assessment of risks in biotechnological processing (BAP 110 UK). One objective of the work is to assess and compare the suitability of air sampling monitors for detecting breaches of containment during bio-processing. Three viable samplers and two clean room monitors were used to sample an aerosol of a spore suspension generated in a containment cabinet. Differences in collection efficiency are explained in terms of droplet size effects. Future and related work is briefly discussed.

Keywords

aerobiological monitoring aerosols bioprocess plant safety containment droplet size measurement 

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References

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    Stewart, I.W., Watson, R.H. and Leaver, G. (1987) “Evaluation of aerobiological monitors”. Chapter 37 in Verrall, M.S. and Hudson, M.J. (Eds) “Separations for Biotechnology”. Ellis Horwood Ltd, Chichester, UK.Google Scholar
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    Norton, M., Leaver, G. and Melling, J. (1987) “Safety Aspects of Bioprocessing: The Implications of the Industrial Biosafety Club”. The World Biotech Report 1987, Vol. 1, Part 1, pp 51–54, Online Publications, Pinner, UK.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • I. W. Stewart
    • 1
  • G. Leaver
    • 1
  1. 1.Biotechnology and Separations DivisionWarren Spring LaboratoryStevenageUK

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