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Corticotropin-Releasing Factor in Depression and Suicide

  • C. M. Banki
  • G. Bissette
  • C. B. Nemeroff
  • M. Arató

Abstract

Hypothalamic-pituitary-adrenocortical (HPA) axis hyperactivity is one of the most consistent findings in major depression (Carroll 1982; Halbreich et al. 1985; Carroll 1985). However, the regulation of HPA activity in humans is highly complex, and the mechanism of Cortisol overproduction together with impaired suppressibility by exogenous steroids is far from being understood. One possibility is a primary overproduction of the principal adrenocorticotropic hormone (ACTH)-stimulating hypothalamic substance: corticotropin-releasing factor (CRF), a 41-amino acid peptide isolated and characterized by Vale et al. (1981). At present there are two lines of evidence favoring this hypothesis: first, Gold et al. (1984) showed that depressed patients responded with a lower ACTH rise to intravenously administered CRF than nondepressed patients or healthy controls, consistent with a down regulation of the pituitary CRF receptors. Second, our group reported that in psychiatric patient groups from different countries (including the USA, Sweden, and Hungary) there was a fairly specific increase in lumbar CSF CRF concentration in subjects with major unipolar and bipolar depression compared with other diagnostic groups (schizophrenia, senile dementia, anxiety disorders, etc.) or with healthy controls (Nemeroff et al. 1984; Bissette et al. 1985).

Keywords

Anxiety Disorder Suicidal Behavior Dexamethasone Suppression Test Depressive Syndrome Adjustment Disorder 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Banki CM, Arato M, Papp Z, Kurcz M (1984) Cerebrospinal fluid amine metabolites and neuroendocrine findings: biochemical markers in suicidal patients. J Affect Disord 6:341–350PubMedCrossRefGoogle Scholar
  2. Banki CM, Bissette G, Arato M, O’Connor L, Nemeroff CB (1987) Cerebrospinal fluid corticotrophin-like immunoreactivity in depression and schizophrenia. Am J Psychiatry 144:873–877.PubMedGoogle Scholar
  3. Bissette G, Spielman F, Stanley M, Banki CM, Finke M, Träskman L, Arato M, Nemeroff CB (1985) Further studies of CRF-like immunoreactivity in patients with affective disorders. Soc Neurosci Abstr 11:133Google Scholar
  4. Carroll BJ (1982) The dexamethasone suppression test for melancholia. Br J Psychiatry 140:292–304PubMedCrossRefGoogle Scholar
  5. Carroll BJ (1985) Dexamethasone suppression test: a review of contemporary confusion. J Clin Psychiatry 46:13–24PubMedGoogle Scholar
  6. Gold PW, Chrousos G, Kellner C, Post RM, Roy A, Avgerinos P, Schulte H, Loriaux LD (1984) Psychiatric implications of basic and clinical studies with corticotropin-releasing factor. Am J Psychiatry 141:619–627PubMedGoogle Scholar
  7. Halbreich U, Asnis GM, Schindledecker R, Zumoff B, Nathan S (1985) Cortisol secretion in endogenous depression. Arch Gen Psychiatry 42:904–908PubMedCrossRefGoogle Scholar
  8. Nemeroff CB, Widerlöv E, Bissette G, Walleus H, Eklund K, Kilts CD, Vale W, Loosen PT (1984) Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients. Science 226:1342–1344PubMedCrossRefGoogle Scholar
  9. Träskman L, Åsberg M, Bertilsson L, Sjöstrand L (1981) Monoamine metabolites in CSF and suicidal behavior. Arch Gen Psychiatry 38:631–637PubMedCrossRefGoogle Scholar
  10. Vale W, Spiess J, Rivier C, Rivier J (1981) Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science 213:1394–1397PubMedCrossRefGoogle Scholar
  11. Van Praag HM (1984) Depression, suicide, and serotonin metabolism in the brain. In: Post RM, Ballenger JC (eds) Neurobiology of mood disorders. Williams and Wilkins, Baltimore, pp 601–618Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • C. M. Banki
  • G. Bissette
  • C. B. Nemeroff
  • M. Arató

There are no affiliations available

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