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Intestinal Absorption of Aluminium in Rats: Kinetics, Influence of the Uremic State and Simultaneous Administration of Fluoride

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Generalized Bone Diseases
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Abstract

When Aluminium (Al) was found to be involved with the pathogenesis of dialysis encephalopathy, the contaminated dialysate was the predominant source of poison (Alfrey et al. 1976). However, nowadays the oral route seems to be of equal importance in uremic patients who are ingesting large doses of Al-containing, phosphate binding gels. This may be particularly true in Al-related bone disease. Furthermore, it seems possible that the intestinal absorption of Al from ordinary dietary sources may be enhanced in the uremic state.

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References

  • Alfrey, A.C. (1985): The case against aluminium affecting pararthyroid function. Am. J. Kidney Disease 6, 309–312.

    CAS  Google Scholar 

  • Alfrey, A.C., G.R. Lendre, W.d. Kaehny (1976): The dialysis encephalopathy syndrome. Possible aluminium intoxication. N. Engl. J. Med. 294, 184–188.

    Article  PubMed  CAS  Google Scholar 

  • Ihle, B.U. and G.J. Becker (1985): Gastrointestinal absorption of aluminium. Am. J. Kidney Disease 6, 302–305.

    CAS  Google Scholar 

  • Ittel, T.H., B. Buddington, N.L. Miller, A.C. Alfrey (1986): Enhanced gastrointestinal absorption of aluminium in uremic rats. Kidney Int. 29, 1261.

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  • Lendre, G.R. and A.C. Alfrey (1976): Measuring picogram amounts of aluminium in biological tissue by flameless atomic absorption analysis of a chelate. Clin. Chem. 22, 53–56.

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  • Mayor, G.H., S.M. Sprague, M.R. Hourani, T.C. Sanchez (1980): Parathyroid hormone-mediated aluminium deposition and egress in the rat. Kidney Int. 17, 40–44.

    Article  PubMed  CAS  Google Scholar 

  • Spencer, H., L. Kramer, C. Norris, E. Wiatrowski (1980): Effect of aluminium hydroxide on fluoride metabolism. Clin. Pharmacol. Ther. 28, 529–535.

    Article  PubMed  CAS  Google Scholar 

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© 1987 Springer-Verlag Berlin Heidelberg

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Ittel, T.H., Sieberth, HG., Eikmann, T., Buddington, B., Miller, N.L., Alfrey, A.C. (1987). Intestinal Absorption of Aluminium in Rats: Kinetics, Influence of the Uremic State and Simultaneous Administration of Fluoride. In: Kuhlencordt, F., Dietsch, P., Keck, E., Kruse, HP. (eds) Generalized Bone Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73346-8_17

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  • DOI: https://doi.org/10.1007/978-3-642-73346-8_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-18789-9

  • Online ISBN: 978-3-642-73346-8

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