Investigations into the inheritance of serum IgD concentration
Population studies repeatedly showed a trimodal distribution of the serum IgD concentration in adults (Becker et al. 1969; Dunnette et al. 1977; Rowe and Fahey 1965). Consequently, a genetic polymorphism of the serum IgD level was suggested. But also investigations in twins (Allansmith et al. 1969; Lee et al. 1980) and the correlation between IgD concentration in the serum and in the Gm phenotype (Walzer and Kunkel 1974) indicate genetic influences. Family studies (Dunnette et al. 1978) yielded evidence for an autosomal-recessive inheritance of an allele which is responsible low serum IgD concentration.
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