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Investigations into the inheritance of serum IgD concentration

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Advances in Forensic Haemogenetics

Part of the book series: Advances in Forensic Haemogenetics ((HAEMOGENETICS,volume 2))

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Abstract

Population studies repeatedly showed a trimodal distribution of the serum IgD concentration in adults (Becker et al. 1969; Dunnette et al. 1977; Rowe and Fahey 1965). Consequently, a genetic polymorphism of the serum IgD level was suggested. But also investigations in twins (Allansmith et al. 1969; Lee et al. 1980) and the correlation between IgD concentration in the serum and in the Gm phenotype (Walzer and Kunkel 1974) indicate genetic influences. Family studies (Dunnette et al. 1978) yielded evidence for an autosomal-recessive inheritance of an allele which is responsible low serum IgD concentration.

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References

  • Allansmith M, McClellan B, Butterworth M (1969) The influence of heredity and environment on human immunoglobulin levels. J Immunol 102: 1504–1510

    PubMed  CAS  Google Scholar 

  • Becker W, Schwick HG, Störiko K (1969) Immunologic determination of proteins found in low concentration in human serum. Clin Chem 15: 649–660

    PubMed  CAS  Google Scholar 

  • Dunnette SL, Gleich GJ, Miller RD, Kyle RA (1977) Measurement of IgD by a double antibody radioimmunoassay: demonstration of an apparent trimodal distribution of IgD levels in normal human sera. J Immunol 119: 1727–1731

    PubMed  CAS  Google Scholar 

  • Dunnette SL, Gleich GJ, Weinshilboum RM (1978) Inheritance of low serum immunoglobulin D. J clin Invest 62: 248–255

    Article  PubMed  CAS  Google Scholar 

  • Lee SK, Metrakos JD, Tanaka KR, Heiner DC (1980) Genetic influence on serum IgD levels. Pediat Res 14: 60–63

    PubMed  CAS  Google Scholar 

  • Rowe DS, Fahey JL (1965) A new class of human immunoglobulins. II. Normal serum IgD. J exp Med 121: 185–199

    Article  PubMed  CAS  Google Scholar 

  • Spiegelberg HL (1977) The structure and biology of human IgD. Immunological Rev 37: 3–24

    Article  CAS  Google Scholar 

  • Walzer PD, Kunkel HG (1974) The correlation of serum IgD concentration with Gm allotype. J Immunol 113: 274–278

    PubMed  CAS  Google Scholar 

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© 1988 Springer-Verlag Berlin Heidelberg

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Keil, W., Rose, M. (1988). Investigations into the inheritance of serum IgD concentration. In: Mayr, W.R. (eds) Advances in Forensic Haemogenetics. Advances in Forensic Haemogenetics, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73330-7_15

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  • DOI: https://doi.org/10.1007/978-3-642-73330-7_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-18765-3

  • Online ISBN: 978-3-642-73330-7

  • eBook Packages: Springer Book Archive

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