Investigations into the inheritance of serum IgD concentration

  • W. Keil
  • M. Rose
Conference paper
Part of the Advances in Forensic Haemogenetics book series (HAEMOGENETICS, volume 2)


Population studies repeatedly showed a trimodal distribution of the serum IgD concentration in adults (Becker et al. 1969; Dunnette et al. 1977; Rowe and Fahey 1965). Consequently, a genetic polymorphism of the serum IgD level was suggested. But also investigations in twins (Allansmith et al. 1969; Lee et al. 1980) and the correlation between IgD concentration in the serum and in the Gm phenotype (Walzer and Kunkel 1974) indicate genetic influences. Family studies (Dunnette et al. 1978) yielded evidence for an autosomal-recessive inheritance of an allele which is responsible low serum IgD concentration.




Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Allansmith M, McClellan B, Butterworth M (1969) The influence of heredity and environment on human immunoglobulin levels. J Immunol 102: 1504–1510PubMedGoogle Scholar
  2. Becker W, Schwick HG, Störiko K (1969) Immunologic determination of proteins found in low concentration in human serum. Clin Chem 15: 649–660PubMedGoogle Scholar
  3. Dunnette SL, Gleich GJ, Miller RD, Kyle RA (1977) Measurement of IgD by a double antibody radioimmunoassay: demonstration of an apparent trimodal distribution of IgD levels in normal human sera. J Immunol 119: 1727–1731PubMedGoogle Scholar
  4. Dunnette SL, Gleich GJ, Weinshilboum RM (1978) Inheritance of low serum immunoglobulin D. J clin Invest 62: 248–255PubMedCrossRefGoogle Scholar
  5. Lee SK, Metrakos JD, Tanaka KR, Heiner DC (1980) Genetic influence on serum IgD levels. Pediat Res 14: 60–63PubMedGoogle Scholar
  6. Rowe DS, Fahey JL (1965) A new class of human immunoglobulins. II. Normal serum IgD. J exp Med 121: 185–199PubMedCrossRefGoogle Scholar
  7. Spiegelberg HL (1977) The structure and biology of human IgD. Immunological Rev 37: 3–24CrossRefGoogle Scholar
  8. Walzer PD, Kunkel HG (1974) The correlation of serum IgD concentration with Gm allotype. J Immunol 113: 274–278PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • W. Keil
    • 1
  • M. Rose
    • 1
  1. 1.Institute for Forensic MedicineHumboldt UniversityBerlinGermany

Personalised recommendations