Abstract
HLA is a powerful tool, as it is the most polymorphic genetic system known in man, determined by heredity in a known way, unchangeable during the life of an individual and observable by relatively simple blood tests. The knowledge of HLA polymorphisms may be applied to the study of the relationship between populations. The proportions of any particular set of antigens and those of the genes on which they depend, tend to remain constant from generation to generation, and any changes due to mutation, natural selection, and genetic drift are likely to be very slow. However, populations separated for many generations, such as the South African (SA) Negroes, the Caucasoids and the San, show variations in the frequencies of their HLA alleles and haplotypes.
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© 1988 Springer-Verlag Berlin Heidelberg
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du Toit, E.D. (1988). HLA Polymorphisms in Southern African Populations. In: Mayr, W.R. (eds) Advances in Forensic Haemogenetics. Advances in Forensic Haemogenetics, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73330-7_10
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DOI: https://doi.org/10.1007/978-3-642-73330-7_10
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