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Short- and Long-Term Effects of Withdrawal Therapy in Drug-Induced Headache

  • H.-C. Diener
  • W. D. Gerber
  • S. Geiselhart
  • J. Dichgans
  • E. Scholz
Part of the Advances in Applied Neurological Sciences book series (NEUROLOGICAL, volume 5)

Abstract

Ergotamine preparations were used in the treatment of migraine attacks for the first time at the turn of this century. Between 1934 and 1946, Horton and coworkers performed several studies on the action of ergotamine, dihydroergotamine, and combinations with caffeine and barbiturates in the treatment of acute migraine attacks (Logan and Allen 1934; Horton et al. 1945, 1948; Peters 1953; Horton 1961). But already in 1951 (Peters and Horton 1951) and in a more extended study in 1963 (Horton and Peters 1963), the authors realized that patients with periodic headache (migraine and tension headache) who had used excessive amounts of ergotamine preparations for prolonged periods not only developed signs of ergotamine intoxication (vasospastic disturbances in the extremities, peripheral neuropathy), but in addition they also developed chronic headache.

Keywords

Migraine Attack Chronic Headache Tension Headache Calcium Entry Blocker Headache Intensity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • H.-C. Diener
    • 1
  • W. D. Gerber
    • 1
  • S. Geiselhart
    • 1
  • J. Dichgans
    • 1
  • E. Scholz
    • 1
  1. 1.Department of NeurologyUniversity of TübingenTübingenFederal Republic of Germany

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