Transforming Growth Factor-α
Transforming growth factor-α (TGF-α) was first detected in the culture medium of certain retrovirus-transformed cell lines as an activity which binds to the receptor for epidermal growth factor (EGF) and thereby inhibits the binding of EGF. Subsequent examination showed that this factor is made by many other transformed cell lines but not by adult normal cells in culture (Todaro et al. 1985). Addition of sarcoma growth factor, as it was first called, to rat fibroblasts of the NRK cell line reversibly induced profound morphological changes and colony-forming ability in soft agar (De Larco and Todaro 1978; Todaro et al. 1985). The capacity of this factor to confer a transformed phenotype upon NRK cells, together with the fact that it is synthesized by transformed cells, led to the name transforming growth factor.
KeywordsEpidermal Growth Factor Receptor Epidermal Growth Factor Receptor mRNA Simian Sarcoma Virus Profound Morphological Change Adult Normal Cell
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