Suppression of the Neoplastic Phenotype
The concept that neoplasia results from an accumulation of somatic mutations in the tumour lineage is heuristically extremely useful. Strong support for this hypothesis has been provided by the demonstration that suitably altered proto-oncogenes can induce a neoplastic phenotype when introduced into normal recipient cells. However, activated oncogenes that behave in this phenotypically “dominant” fashion have been detected so far in only a minority of tumours and therefore the genetic basis of neoplasia in most cancers remains obscure. There are at least four explanations for the frequent failure to implicate positively acting oncogenes.
KeywordsLymphoma Leukemia Sarcoma Fibrosarcoma
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