Multiple Factors Involved in B-Cell Tumorigenesis
This chapter considers the hypothesis that activation of the c-myc locus by chromosomal translocation to a site adjacent to one of the immunoglobulin loci represents an essential, rate-limiting step in the development of Burkitt’s lymphoma, mouse plasmacytoma, and rat immunocytoma. It also describes a possible mechanism by which an activated c-myc affects susceptible cells, as well as additional factors which may contribute to the acquisition of a malignant phenotype.
KeywordsImmunoglobulin Heavy Chain Trans Location Immunoglobulin Locus Mouse Plasmacytoma Genetic Transposition
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