Abstract
The p53 cellular tumor antigen is a phosphoprotein which is overproduced in a wide variety of neoplastic cells (reviewed by Klein 1982; Crawford 1983; Rotter and Wolf 1984). High p53 mRNA levels are also seen in certain nonmalignant cells, including embryonic tissue and exponentially growing, non-transformed cultured cell lines, but expression is low in most adult organs (Dippold et al. 1981; Rogel et al. 1985). This chapter reviews the evidence which suggests that p53 plays a role both in normal cell proliferation and in neoplastic transformation. It also discusses the question of how p53 expression levels are regulated.
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© 1986 Springer-Verlag Berlin Heidelberg
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Oren, M. (1986). p53: Molecular Properties and Biological Activities. In: Kahn, P., Graf, T. (eds) Oncogenes and Growth Control. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73325-3_39
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DOI: https://doi.org/10.1007/978-3-642-73325-3_39
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-18760-8
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