Properties of the myc and myb Gene Products
The myc and myb oncogenes were originally discovered as the transforming genes in certain avian retrovirus strains and have recently also been implicated in the genesis of human hematopoietic neoplasms. Their gene products were the first transforming proteins found to be localized in the nucleus and are therefore possibly involved in the regulation of gene expression. In this article some of the properties of viral and cellular myc and myb proteins will be reviewed and their possible roles during normal and neoplastic processes discussed.
KeywordsAvian Myeloblastosis Virus Cellular Sequence
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