RAS Genes and Growth Control in the Yeast Saccharomyces cerevisiae
Ras 1 genes activated by point mutations have dramatic effects on the proliferation of mammalian cells (see Marshall, this Vol. and Land, this Vol.). However, the physiological function of the proteins they encode is not known. The identification of RAS genes in yeast has made it possible to study their function using the sophisticated genetic and biochemical techniques available in this organism. This review describes data which indicate that RAS proteins are elements of the cAMP effector pathway in S. cerevisiae, and then discusses RAS function at the molecular level.
KeywordsAdenylate Cyclase Nonfermentable Carbon Source Pmol cAMP Adenylate Cyclase Gene Significant Amino Acid Sequence Homology
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