Epidermal Growth-Factor Mediation of S6 Phosphorylation During the Mitogenic Response: A Novel S6 Kinase
The 40S ribosomal protein S6 undergoes extensive phosphorylation during the processes of tissue regeneration, development, cell growth and transformation. Much attention has recently been focused on the role of this event in protein translation and the mechanisms by which it is regulated (Gressner and Wool 1974; Decker 1981; Nielsen et al. 1982; Thomas et al. 1982). This chapter reviews briefly what is known about S6 function in translation and then discusses in greater detail how its multiple phosphorylation is regulated by EGF and, to a lesser extent, by other mitogens during the mitogenic response.
KeywordsTyrosine Fluoride Vanadate Serine Sarcoma
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