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Epidermal Growth-Factor Mediation of S6 Phosphorylation During the Mitogenic Response: A Novel S6 Kinase

  • George Thomas

Abstract

The 40S ribosomal protein S6 undergoes extensive phosphorylation during the processes of tissue regeneration, development, cell growth and transformation. Much attention has recently been focused on the role of this event in protein translation and the mechanisms by which it is regulated (Gressner and Wool 1974; Decker 1981; Nielsen et al. 1982; Thomas et al. 1982). This chapter reviews briefly what is known about S6 function in translation and then discusses in greater detail how its multiple phosphorylation is regulated by EGF and, to a lesser extent, by other mitogens during the mitogenic response.

Keywords

Ribosomal Protein Quiescent Cell Mitogenic Response Meiotic Maturation Eukaryotic Ribosomal Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • George Thomas

There are no affiliations available

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