Mutational Analysis of v-erbB Oncogene Function
The v-erbB oncogene is contained in two strains of avian erythroblastosis virus (AEV) and encodes their capacity to cause erythroleukemia and sarcomas in chickens. Recent work has revealed that the v-erbB gene product represents a truncated and mutated version of the EGF receptor (Downward et al. 1984; Ullrich et al. 1984). This finding was surprising in light of the fact that AEV in hematopoietic cell lineages selectively transforms erythroid cells, which are not known to express the epidermal growth factor (EGF) receptor. Sequence comparisons showed that v-erbB is also related to the family of oncogenes encoding tyrosine kinases (Yamamoto et al. 1983).
KeywordsMutate Epidermal Growth Factor Receptor Erythroid Cell Epidermal Growth Factor Receptor Gene erbB Gene Plasma Membrane Localization
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