Role of Prostaglandins in Intestinal Fluid Secretion

  • E. Beubler
Conference paper


In the late 1960s endogenous prostaglandins (PGs) were assumed to be related to certain types of human diarrhea, diarrhea being one of the most prominent side effects associated with the clinical use of PGE and PGE Meanwhile, secretory as well as motor functions have been shown to be involved in PG-induced diarrhea. Despite the well documented effects of PGs on intestinal smooth muscle, which may partly contribute to diarrhea and particularly to the abdominal colics that accompany it, the probably more important properties are those responsible for intestinal secretion.


Adenylate Cyclase Cholera Toxin Morphine Withdrawal Intestinal Secretion Intestinal Smooth Muscle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Field M (1981) Role of prostaglandins in the regulation of intestinal electrolyte transport. Prostaglandins (Suppl) 21: 73–79CrossRefGoogle Scholar
  2. 2.
    Beubler E, Juan H (1978) PGE-release, blood flow, and transmucosal water movement after mechanical stimulation of the rat jejunal mucosa. Naunyn-Schmiedeberg’s Arch Pharmacol 305: 91–5PubMedCrossRefGoogle Scholar
  3. 3.
    Rask-Madsen J, Bukhave K (1981) The role of prostaglandins in diarrhea. Clin Res Rev 1 (Suppl 1): 33–4Google Scholar
  4. 4.
    Hawkey CJ, Rampton DS (1985) Prostaglandins and the gastrointestinal mucosa: Are they important in its function, disease, or treatment? Gastroenterology 89: 1162–88.PubMedGoogle Scholar
  5. 5.
    Beubler E, Bukhave K, Rask-Madsen J (1986) Significance of calcium for the prostaglandin E2-mediated secretory response to 5-hydroxytryptamine in the small intestine of the rat in vivo. Gastroenterology 90: 1972–7PubMedGoogle Scholar
  6. 6.
    Beubler E, Kollar G (1985) Stimulation of PGE2 synthesis and water and electrolyte secretion by senna anthraquinones is inhibited by indomethacin. J Pharm Pharmacol 37: 248–51PubMedCrossRefGoogle Scholar
  7. 7.
    Beubler E, Juan H (1977) The function of prostaglandins in transmucosal water movement and blood flow in the rat jejunum. Naunyn-Schmiedeberg’s Arch Pharmacol 299: 89–94PubMedCrossRefGoogle Scholar
  8. 8.
    Bukhave K, Rask-Madsen J (1980) Saturation kinetics applied to in vitro effects of low prostaglandin E2 and F2α concentrations on ion transport across human jejunal mucosa. Gastroenterology 78: 32–42PubMedGoogle Scholar
  9. 9.
    Field M (1981) Secretion of electrolytes and water by mammalian small intestine. In: Johnson LR, ed Physiology of the gastrointestinal tract. New York: Raven Press 963–82.Google Scholar
  10. 10.
    Kimberg DV, Field M, Johnson J, Henderson A, Gershon E (1971) Stimulation of intestinal mucosal adenylcyclase by cholera enterotoxin and prostaglandins. J Clin Invest 50: 1218–30PubMedCrossRefGoogle Scholar
  11. 11.
    Kimberg DV, Field M, Gershon E, Henderson A (1974) Effects of prostaglandins and cholera toxin on intestinal mucosal cyclic AMP accumulation. J Clin Invest 53: 941–9.PubMedCrossRefGoogle Scholar
  12. 12.
    Beubler E, Bukhave K, Rask-Madsen J (1984) Colonic secretion mediated by prostaglandin E2 and 5-hydroxytryptamine may contribute to diarrhea due to morphine withdrawal in the rat. Gastroenterology 87: 1042–8PubMedGoogle Scholar
  13. 13.
    Wals A, Gotterer GS, Rajendra GR et al (1977) Effect of indomethacin on cholera-induced fluid movement, unidirectional sodium fluxes, and intestinal cAMP. Gastroenterology 72: 106–10Google Scholar
  14. 14.
    Beubler E, Kollar G, Saria A, Bukhave K, Rask-Madsen J (1987) Role of 5-hydroxytryptamine and PGE2 in cholera-induced fluid secretion by the rat jejunum in vivo. J Physiol 382: 46 PGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • E. Beubler

There are no affiliations available

Personalised recommendations