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Smoking and Ulcer Healing — Role for Prostaglandins?

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Prostaglandins and Leukotrienes in Gastrointestinal Diseases

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Abstract

Cigarette smoking is causally related to duodenal ulcer (DU) and gastric ulcer (GU) disease: there is an increased incidence of DU [1] and GU [2] in patients who are smokers compared with non-smokers; there is a dose-response, in that the greater the number of cigarettes a patient smokes and the longer the history of smoking, the greater the relative risk of developing an ulcer [3]; and cigarette smoking is associated with pathophysiological abnormalities which may predispose to or aggravate duodenal or gastric ulcer disease (Table 1). In addition, cigarette smoking is associated with a slower rate of healing of duodenal and gastric ulcers during treatment with a variety of non-prostaglandin ulcer-healing drugs or placebo [4].

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Authors
  1. E. J. S. Boyd
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  2. K. G. Wormsley
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Editor information

Editors and Affiliations

  1. Medizinische Klinik mit Poliklinik, Universität Erlangen-Nürnberg, Krankenhausstraße 12, D-8520, Erlangen, Germany

    Wolfram Domschke (Prof. Dr. med.) (Prof. Dr. med.)

  2. Krankenhaus Bethanien, Martinistraße 44-66, D-2000, Hamburg 20, Germany

    Hanns Gerd Dammann (Prof. Dr. med.) (Prof. Dr. med.)

  3. Arbeitsgruppe Experimentelle Klinische Medizin, Ruhr-Universität Bochum, D-4630, Bochum 1, Germany

    B. M. Peskar (Prof. Dr. med.) (Prof. Dr. med.)

  4. 1. Medizinische Klinik, St. Markus-Krankenhaus, Wilhelm-Epstein-Straße 2, D-6000, Frankfurt/Main 50, Germany

    K. H. Holtermüller (Prof. Dr. med.) (Prof. Dr. med.)

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© 1988 Springer-Verlag Berlin Heidelberg

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Boyd, E.J.S., Wormsley, K.G. (1988). Smoking and Ulcer Healing — Role for Prostaglandins?. In: Domschke, W., Dammann, H.G., Peskar, B.M., Holtermüller, K.H. (eds) Prostaglandins and Leukotrienes in Gastrointestinal Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73316-1_45

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  • DOI: https://doi.org/10.1007/978-3-642-73316-1_45

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-18744-8

  • Online ISBN: 978-3-642-73316-1

  • eBook Packages: Springer Book Archive

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