Heartburn and Mucosal Barrier Weakness
Experimental cytoaggression by different drugs is clearly established.
The major symptom of many dyspeptic patients is epigastric heartburn (quite different from pyrosis, which is a retrosternal and ascending pain), which appears shortly after ingestion of some beverages (white wine, coffee) or meals (jam or spices). These nutrients may possibly act as cytoaggressors.
We have found  in normal subjects that montmorrillonnite, an inert and neutral clay, reduces the aggressive effect of aspirin not only when they are both ingested at the same time, but also when aspirin is ingested 24 h after the clay (Tarnasky et al. have observed the same with glucagon ).
According to the general law linking pathological and physiological mechanisms (the first being either an enhancement or a diminution of the second), one may hypothesize that if some substances are able to increase the resistance of the mucosa, some others could produce the opposite: a weakening of the mucosal barrier.
KeywordsWhite Wine Bile Reflux Nonulcerous Dyspepsia Mucosal Defect Dyspeptic Patient
Unable to display preview. Download preview PDF.
- 1.Blum A, Heartburn and gastrooesophageal reflux. Personal communicationGoogle Scholar
- 2.Florent C, Flourie B, Bernier JJ (1985) Effets d’un pansement anti-acide sur les modifications de la différence de potential gastrique induite par l’aspirine chez l’homme. Gastroenterol Clin Biol 8: 359–363Google Scholar
- 6.Kingham GC, Dawson AM (1985) Origin of chronic right upper quadrant pain. Gut 26: 783–788Google Scholar
- 7.Malagelada J (1986) Dyspepsia, Workshop World Congress São PauloGoogle Scholar