A Controlled Trial of CPD-Choline Administration in Premature Infants with Respiratory Distress Syndrome

  • A. Valls-Soler
  • P. Sanjurjo
  • I. Lopez de Heredia
Conference paper


CPD-choline (Citidin-5′-diphosphate of choline) is a known precursor of DPPL (dipalmitoyl-phosphatidyl-choline), the principal component of pulmonary surfactant [1]. The CPD-choline incorporation pathway is the main mechanism of de novo synthesis of DPPL in developing mammalian lung [2]. It has been shown that the administered CPD-choline is incorporated into the DPPL synthetized by adult rat lung, and by fetal lung tissure when given to pregnant rats [3]. There is also some evidence that CPD-choline may stimulate the synthesis of phosphatidic acids in both cerebral tissue [4], and in fetal rabbit lung [5]. Katyal and Lombardi [6] have shown that fetuses born to pregnant, diet-deficient rats, died from progressive respiratory distress in the first hours of life.


Phosphatidic Acid Pulmonary Surfactant Surfactant Replacement Therapy Lecithin Fraction Fetal Rabbit Lung 
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  1. 1.
    Farrell PM (1973) Regulation of pulmonary lecithin synthesis. In: Villaee CA, Villae DB, Zucherman J (eds) Respiratory distress syndrome. Academic, New York, pp 311–320Google Scholar
  2. 2.
    Farrell PM, Mamosh M (1978) The biochemistry of fetal lung development. Clin Perinatol 5: 197–229PubMedGoogle Scholar
  3. 3.
    Hayashi Y (1973) Experimental studies on the effects of CPD-choline on pulmonary surfactant. Kanasai Ika Daigaku Zasshi (Osaka) 25: 227–252Google Scholar
  4. 4.
    Possmayer F (1974) CPD-choline reversal of the CMP and CTP inhibition of phosphatidic acid synthesis by rat brain preparation. Biochem Biophys Res Commun 61: 1415–1421PubMedCrossRefGoogle Scholar
  5. 5.
    Kotas RV, Clements JA (1977) Positive effects of added choline on fetal rabbit pulmonary surfactant production. Physiologist 20: 52–64Google Scholar
  6. 6.
    Katyal SL, Lombardi B (1978) Effects of dietary choline and N,N-Dimethylaminoethanol in lung phospholipid and surfactant of newborn rats. Pediatr Res 12: 952–955PubMedCrossRefGoogle Scholar
  7. 7.
    Fujiwara T, Chida S, Watabe Y, Macta H, Morita T, Abe T (1980) Artificial surfactant therapy in hyaline-membrane disease. Lanceti: 55–59Google Scholar
  8. 8.
    Hallman M, Jävenpää AL, Pohjavuori M (1986) Respiratory distress syndrome and inositol supplementation in preterm infants. Arch Dis Child 61: 1076–1083PubMedCrossRefGoogle Scholar
  9. 9.
    Nishimura K, Goshii N (1972) Treatment of idiopathic respiratory distress syndrome with nicholine. Jpn Med News (Tokyo) 9: 1–4Google Scholar
  10. 10.
    Goldsmith JP, Korotkin EH (eds) (1981) Assisted ventilation of the Neonate. Saunders, Philadelphia, pp 101–127Google Scholar
  11. 11.
    Valls-Soler A, Sanjurjo P (1977) Postnatal L/S ratio and palmitic acid percentage as predictors of recovery from IRDS. Pediatr Res 11: 1024Google Scholar
  12. 12.
    Wauer RR (1983) Medical treatment of neonatal hyaline-membrane disease using Bromhexine, Ambroxol, and CPD-Choline. In: Cosmi EV, Scarpelli EM (eds) Pulmonary surfactant system. Elsevier Science, Amsterdam, pp 173–188Google Scholar
  13. 13.
    Sappa M, Gramiccioni E, Manzari V, Dotta F, Matzeu M (1974) Effeto sul contenuto di fosfolipidi pel pulmone del feto di coniglio determinato dalla somministrazione de Citicolina alla madre. Mind 65: 3595–3598Google Scholar
  14. 14.
    Finilä MJ, Osterlind K, Lethi H (1978) Die Behandlung des idiopathischen Atemnotsyndrom mit Ambroxol. Atemwegs Lungenkr 4: 62–67Google Scholar
  15. 15.
    Renovanz HD, Keuth U (1978) Respiratory Distress Syndrom und Ambroxol Therapie — Teamstudien an Kinderkliniken. Atemwegs Lungenkr 4: 50–61Google Scholar
  16. 16.
    Endo H (1973) Changes in surfactant lecithin, total lecithin, L/S ratio, and total surfactant lipids in the amniotic fluid of pregnant women due to the administration of CPD-choline and Dexametasone. XI Meeting of the Japanese Academy of Neonatology (Tokyo) 73: 354Google Scholar
  17. 17.
    Farrell P, Zachman RD (1972) Enhancement of lecithin synthesis and phosphorylcholine glyceride transferase activity in the fetal rabbit lung after corticosteroid administration. Pediatr Res 6: 337Google Scholar
  18. 18.
    Chida N (1973) Biosynthesis of lecithin in the lung in the growing stage including behavior of choline and CPD-choline. Tohaku J Exp Med (Tokyo) 110: 273–281Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • A. Valls-Soler
  • P. Sanjurjo
  • I. Lopez de Heredia

There are no affiliations available

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