In Vivo Tests for Evaluation of Pulmonary Surfactant

  • B. Lachmann
Conference paper


Before using surfactant preparations in animal experiments or in clinical trials, it is necessary that they fulfill specific physical properties [5, 9]. Some of these essential physical requirements for an effective lung surfactant have been reviewed by many workers [1, 4, 7, 27]. However, different clinical results concerning arterial oxygen tension have been reported. A marked improvement in arterial oxygen tension after surfactant replacement has been reported by Fujiwara et al. [6], whereas no effect on arterial oxygen tension was observed by Milner et al. [22], Morley et al. [23] and Wilkinson et al. [32]. All these workers used a surfactant which was highly effective in in vitro studies. This poses the question as to whether the physical characteristics of surfactant, obtained through in vitro studies, can be also be considered as a method of testing a preparation which has to be physiologically active in the lung.


Adult Respiratory Distress Syndrome Pulmonary Surfactant Arterial Oxygen Tension Viral Pneumonia Peak Airway Pressure 
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© Springer-Verlag Berlin Heidelberg 1988

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  • B. Lachmann

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