Pulmonary Surfactant Effects and Replacement in Oxygen Toxicity and Other ARDS-Type Lung Injuries
In the thirty years since the discovery of surface active material in the alveolar region of the lung, and its fundamental importance for respiration, extensive studies have been directed at characterizing and understanding the pulmonary surfactant system (e.g. [20, 24]). A basic driving force for much of this lung surfactant (LS) research was the discovery in 1959 that the respiratory distress syndrome of the premature newborn (RDS) resulted directly from a lack of surfactant-producing type II pneumocytes in the immature lung, giving rise to a primary deficiency in alveolar surfactant at birth . After the fundamental importance of LS for normal respiration was established, extensive research efforts were initiated to develop beneficial exogenous surfactant replacement therapy for neonatal RDS. The pathway to such therapy has been longer than many researchers expected, but since the beginning of this decade, it has become increasingly clear that exogenous surfactant replacement in RDS is highly efficacious in premature infants [e.g. 5, 20 (for review), 27, 29.
KeywordsLung Injury Pulmonary Surfactant Lung Surfactant Hyperoxic Exposure Surfactant Replacement
Unable to display preview. Download preview PDF.
- 1.Avery ME, Mead J (1959) Surface properties in relation to atelectasis and hyaline membrane disease. Am J Dis Child 97: 517–523Google Scholar
- 9.Holm BA, Notter RH, Finkelstein JN, Matalon S (1987) Changes in type II pneumocytes during injury and recovery from hyperoxia. Am Rev Respir Dis 135: 15AGoogle Scholar
- 10.Holm BA, Notter RH (1986) Pulmonary surfactant effects in sublethal hyperoxic lung injury. In: Taylor A, Matalon S, Ward P (eds) Physiology of oxygen radicals. APS, Bethesda, pp 71–86Google Scholar
- 13.Hopewell PC, Murray J (1977) The adult respiratory distress syndrome. In: Shibel EM, Moser KM (eds) Respiratory emergencies. Mosby, St Louis, p 101Google Scholar
- 25.Raj JU (1985) Alveolar liquid pressure in excised air-inflated lungs of mature and immature fetal rabbits (abstr). Physiologist 28: 349Google Scholar
- 27.Robertson B, van Golde LMG, Batenburg JJ (eds) (1984) Pulmonary surfactant. Elsevier, AmsterdamGoogle Scholar
- 29.Shapiro DL, Notter RH, Morin FC, Deluga K, Golub LM, Sinkin R, Weiss K, Cox C (1985) A double-blind randomized clinical trial of a calf lung surfactant extract administered at birth to very premature infants for prevention of the respiratory distress syndrome. Pediatrics 75: 593–599Google Scholar
- 30.Whitsett J, Ohning BL, Ross G, Meuth J, Weaver T, Holm BA, Shapiro DL, Notter RH (1986) Hydrophobic surfactant-associated protein in whole lung surfactant and its importance for biophysical activity in lung surfactant extracts used for replacement therapy. Pediatr Res 20: 460–467PubMedCrossRefGoogle Scholar