Zusammenfassung
Die Empfehlungen, Calcium-Antagonisten für die Sekundärprophylaxe der Atherogenese anzuwenden, ergaben sich vor allem aus Tierexperimenten und Untersuchungen an Zellkulturen. Mit den experimentellen Methoden gelingt es zugleich, Einblicke in Mechanismen zu erhalten, welche den Prozessen zugrundeliegen, durch die die Medikamente Einfluß auf das Wachstum der Plaques haben.
Die Arbeit wurde z. T. durch das Bundesministerium für Forschung und Technologie gefördert. Förderungs.-Nr. 0318846 17
Preview
Unable to display preview. Download preview PDF.
Literatur
Allen JC, Bukoski RD (1982) Current status of vascular smooth muscle subcellular calcium regulation. In: Vascular Smooth Muscle: Metabolic, Ionic, and Contractile Mechanisms ed by MF Crass, CD Barnes, 4: 99–134. Academic Press New York
Apfel H, Betz E (1985) Der elektrische Widerstand von Arterienwänden bei Atheromentwicklung. Berichtsband, 3. Deutsch-Japanischer Kongreß für Angiologie 1984, Heidelberg, herausgegeben von HJ Maurer, Demeter Verlag, Gräfelfing, angio archiv, Z, 91–93
Betz E, Hämmerle H (1984) Arterienwandproliferate and Zellkulturen als Indikatoren für Hemmstoffe der Atherogenese. Funkt Biol Med, 3: 46–55
Betz E, Hämmerle H (1986) Effect of Etofibrate and its metabolites on atheromas of rabbits and on smooth muscle cell cultures. Arzneim-Forsch/ Drug Res, 36: 92–98
Betz E, Hämmerle H, Strohschneider T (1985) Inhibition of smooth muscle cell proliferation and endothelial permeability with Flunarizine in vitro and in experimental atheromas. Res Exp Med, 185: 325–340
Blumlein SL, Sievers R, Kidd P, Parmley WW (1984) Mechanism of protection from atherosclerosis by Verapamil in the cholesterol-fed rabbit. Amer J Cardiol, 54: 884–889
Charp PA, Whitson GL (1980) Calcium and cyclic nucleotide interactions during the cell cycle. In: Nuclear-Cytoplasmic Interactions in the Cell, Academic Press, 309–333
Charp PA, Whitson GL (1982) The central role of calcium in the modulation of cell division. In: Genetic Expression in the Cell Cycle. Cell Biology, ed by GM Padilla, KS McCarty, Academic Press, New York, 393–409
DeFeudis FV (1983) “Calcium-antagonists” and atherosclerosis. Basic studies and therapeutic implications. Life Sciences, 32: 557–563
Doerr W (1979) Die Entwicklung der Arteriosklerose in morphologischer Sicht. In: Gefäßwand — Rezidivprophylaxe — Raynaud-Syndrom, herausgegeben von H Ehringer, E Betz, A Bollinger and E Deutsch, Verlag Gerhard Witzstrock, Baden-Baden Köln New York, 27–38
Forssmann WG (1969) A method for in vivo diffusion tracer studies combining perfusion fixation with intravenous tracer injection. Histochemie, 20: 277–286
Glossmann H, Goll A, Rombusch M, Ferry DR (1985) Molecular pharmacology of Cat+ channels: Receptor binding studies. In: Nimodipine, Pharmacological and Clinical Properties ed by E Betz, K Deck, F Hoffmeister. FK Schattauer-Verlag, Stuttgart New York, 57–73
Harris PJ (1981) Calcium regulation of cell cycle events. In: Mitosis/ Cytokinesis, Cell Biol, ed by AM Zimmerman, A Forer, Academic Press, New York, 29–57
Kling D, Holzschuh T, Betz E (1987) Temporal sequence of morphological alterations in artery walls during experimental atherogenesis — occurrence of leukocytes. Res Exp Med, im Druck
Kramsch DM, Aspen AJ, Apstein CS (1980) Suppression of experimental atherosclerosis by the Ca“-antagonist Lanthanum. J Clin Invest, 65: 967–981
Kramsch DM, Aspen AJ, Rozier U (1981) Atherosclerosis: Prevention by agents not affecting abnormal levels of blood lipids. Science, 213: 1511–1512
Kramsch DM, Chan CT (1978) The effect of agents interfering with soft tissue calcification and cell proliferation of calcific fibrous-fatty plaques in rabbits. Circulat Res, 42: 562–571
Kramsch DM, Chan CT, Aspen AJ, Wells H (1978) Prevention and therapy of induced atherosclerosis in rabbits and monkeys. In: State of Prevention and Therapy in Human Arteriosclerosis and in Animal Models ed by WH Hauss, RW Wissler, R Lehmann, Rhein-Westfäl Akad Wiss, Abh Bd 63, Westdeutscher Verlag Opladen, 153–172
Long WF, Williamson FB (1979) Glycosaminoglycans, calcium ions and the control of cell proliferation. IRCS Med Sci, Z, 429–434
Nakao J, Ito H, Ooyama T, Chang WC, Murota SI (1983) Calcium dependency of aortic smooth muscle cell migration induced by 12-L-Hydroxy-5, 8, 10, 14-eicosatetraenoic acid. Effects of A23187, Nicardipine and Trifluoperazine. Atherosclerosis, 46: 309–319
Roth J, Betz E, Schlote W (1980) Einfluß von 2-Äthyl-3-(4-hydroxybenzoyl)-benzofuran (Benzaron) auf die experimentell erzeugte Atheromatose. Arzneim-Forsch/Drug Res, 30: 1897–1902
Rouleau JL, Parmley WW, Stevens J, Wikman-Coffelt J, Sievers R, Mah-ley RW, Havel RJ, Brecht W (1983) Verapamil suppresses atherosclerosis in cholesterol-fed rabbits. J Amer Coll Cardiol, 1: 1453–1460
Stoclet JC, Lugnier C, Follenius A, Scheftel JM, Gerard D (1985) Calmodulin and calcium regulation: Effect of antagonists. In: Calcium Entry Blockers and Tissue Protection ed by T Godfraind, PM Vanhoutte, S Govoni, R Paoletti, Raven Press, New York, 31–40
Weiss GB (1985) Calcium antagonists as antiatherosclerotic drugs. Drug Development Research, 6: 135–139
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Betz, E. (1988). Experimentelle Grundlagen zur Sekundärprophylaxe arteriosklerotischer Erkrankungen hirnversorgender Gefäße mit Calcium-Antagonisten. In: Hofferberth, B., Brune, G.G. (eds) Calcium-Antagonisten in der Neurologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73300-0_5
Download citation
DOI: https://doi.org/10.1007/978-3-642-73300-0_5
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-18723-3
Online ISBN: 978-3-642-73300-0
eBook Packages: Springer Book Archive