Serotonin Implicated in the Etiology of Seasonal Affective Disorder with Carbohydrate Craving

  • D. O’Rourke
  • J. J. Wurtman
  • R. J. Wurtman


Seasonal affective disorder syndrome (SADS), a variant of atypical depression, is characterized by both affective and appetitive disturbances. Each fall these patients experience depressed mood, decreased energy, lowered interest, difficulty concentrating, and hypersomnia; moreover, they display increased appetite, carbohydrate craving, and weight gain. In spring time, with increasing day length, these symptoms abate, and the patients feel better and become hypomanic (Rosenthal et al. 1984).


Bulimia Nervosa Carbohydrate Intake Atypical Depression Hamilton Depression Scale Mood Score 
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  1. Clayton P (1983) Bipolar illness. In: Psychiatric update, vol. 2: iv. American Psychiatric Association, pp 267–293Google Scholar
  2. Fernstrom J, Wurtman R (1972) Physiological regulation by plasma amino acids. Science 178: 414–416PubMedCrossRefGoogle Scholar
  3. O’Rourke D, Wurtman J, Brzezinski A (1987) Serotonin implicated in etiology of seasonal affective disorder. Psychopharmacol Bull 23: 3Google Scholar
  4. Rosenthal N, Sack D, Gillin C, Lewy A (1984) Seasonal affective disorder. Arch Gen Psychiatry 41: 72–80PubMedGoogle Scholar
  5. Rosenthal N, Sack D, Carpenter C (1985) Antidepressant effects of light in seasonal affective disorder. Am J Psychiatry 142 (2): 163–170PubMedGoogle Scholar
  6. Wurtman J, Wurtman R (1979) Drugs that enhance serotoninergic transmission diminish elective carbohydrate craving by rats. Life Sci 24: 895–904PubMedCrossRefGoogle Scholar
  7. Wurtman J, Wurtman R (1981) Suppression of carbohydrate consumption as snacks anorectic agents: mechanism of action and of tolerance. Raven, New York, pp 169–182Google Scholar
  8. Wurtman J, Wurtman R, Mark S, Tsay R (1985) d-Fenfluramine selectively suppresses carbohydrate snacking by obese subjects. Int J Eat Dis 4(1): 89–99CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • D. O’Rourke
    • 1
  • J. J. Wurtman
    • 2
  • R. J. Wurtman
    • 3
  1. 1.Clinical Research CenterMassachusetts Institute of Technology and Massachusetts General HospitalBostonUSA
  2. 2.Department of Brain and Cognitive SciencesMassachusetts Institute of TechnologyCambridgeUSA
  3. 3.Department of Brain and Cognitive Sciences and Clinical Research CenterMassachusetts Institute of TechnologyCambridgeUSA

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