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Kontrastmittel für die Computertomographie: Status und Zukunft

  • Conference paper
Quo Vadis CT?

Zusammenfassung

Neben der technischen Weiterentwicklung und Optimierung der Computertomographie findet ebenfalls eine Entwicklung neuartiger, verbesserter Kontrastmittel statt. Da die Zeitspanne zwischen Synthese und Registrierung neuer Diagnostika wesentlich größer ist als die Implementierung neuer Technologien, (und im Mittel etwa 8–10 Jahre dauert) wurden zwar in den letzten Jahren mehrere neue Röntgenkontrastmittel registriert, keine Verbindung jedoch speziell für die CT entwikkelt. Bei der Suche nach neuartigen Kontrastmitteln stand bisher die zu verbessernde Verträglichkeit ganz im Vordergrund. Die relativ geringe Empfindlichkeit der Röntgentechnik erfordert die Verwendung hoher Kontrastmittelmengen. Dies führt u.a. zu einer nicht unbeträchtlichen Anzahl von z.T. sehr schweren Nebenwirkungen. Almén schlug bereits 1969 vor, die Verträglichkeit der ionischen Röntgenkontrastmittel durch eine Umwandlung in nichtionische niederosmolare Verbindungen zu verbessern. Als erstes nichtionisches Kontrastmittel wurde Amipaque (Metrizamid) 1972 erstmals klinisch geprüft. Es war der Vorläufer der modernen gebrauchsfertigen monomeren (Iopromid [Ultravist], Iohexol [Omnipaque] und Iopamidol [Solutrast]) und dimeren (Iotrolan [Isovist]) Kontrastmittel [1–7].

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Authors
  1. H.-J. Weinmann
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  2. D. Felsenberg
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  3. H. Müller
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  4. W.-R. Press
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  5. T. Römer
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Editors and Affiliations

  1. Radiologische Klinik, Universitätsklinikum Rudolf-Virchow Standort Charlottenburg Freie Universität Berlin, Spandauer Damm 130, D-1000, Berlin 19, Deutschland

    Claus Claussen  & Roland Felix  & 

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© 1988 Springer-Verlag Berlin Heidelberg

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Weinmann, HJ., Felsenberg, D., Müller, H., Press, WR., Römer, T. (1988). Kontrastmittel für die Computertomographie: Status und Zukunft. In: Claussen, C., Felix, R. (eds) Quo Vadis CT?. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73261-4_30

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  • DOI: https://doi.org/10.1007/978-3-642-73261-4_30

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73262-1

  • Online ISBN: 978-3-642-73261-4

  • eBook Packages: Springer Book Archive

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