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Chemotherapy Studies in Human Non-Small Cell Lung Cancer Xenografts Transplanted in Immune-Deprived Mice

  • J. Carmichael
  • J. F. Smyth
Part of the ESO Monographs book series (ESO MONOGRAPHS)

Abstract

Non-small cell lung cancer lines were successfully established in 15/44 (34%) of tumour biopsies, 9 squamous carcinomas, 5 adenocarcinomas and 1 adenosquamous carcinoma. The overall take rate of all tumour fragments implanted in the first man to mouse passage was low (10%) but this improved in subsequent passages to 57%. Growth rates were variable in all xenografts. Histopathological features were maintained through the first 7 passages although minor changes in differentiation were noted. Chemotherapy studies using maximum tolerated doses of all drugs showed minimal single agent activity. Cis-platinum was the most active drug, exhibiting mean specific growth delay of 1.05 doubling times in 6 tumour lines, with less activity observed with 2 platinum analogues. From these growth delay results significant clinical activity would not be expected, showing correlation with clinical observations. These xenografts offer a useful model for the study of non-small cell lung cancer.

Keywords

Adenosquamous Carcinoma Platinum Analogue Chemotherapy Study Tumour Volume Doubling Time Xenograft Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • J. Carmichael
    • 1
  • J. F. Smyth
    • 1
  1. 1.Imperial Cancer Research Fund, Medical Oncology Unit, Department of Clinical OncologyWestern General HospitalEdinburghScotland, UK

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