Chemotherapy Studies in Human Non-Small Cell Lung Cancer Xenografts Transplanted in Immune-Deprived Mice
Non-small cell lung cancer lines were successfully established in 15/44 (34%) of tumour biopsies, 9 squamous carcinomas, 5 adenocarcinomas and 1 adenosquamous carcinoma. The overall take rate of all tumour fragments implanted in the first man to mouse passage was low (10%) but this improved in subsequent passages to 57%. Growth rates were variable in all xenografts. Histopathological features were maintained through the first 7 passages although minor changes in differentiation were noted. Chemotherapy studies using maximum tolerated doses of all drugs showed minimal single agent activity. Cis-platinum was the most active drug, exhibiting mean specific growth delay of 1.05 doubling times in 6 tumour lines, with less activity observed with 2 platinum analogues. From these growth delay results significant clinical activity would not be expected, showing correlation with clinical observations. These xenografts offer a useful model for the study of non-small cell lung cancer.
KeywordsAdenosquamous Carcinoma Platinum Analogue Chemotherapy Study Tumour Volume Doubling Time Xenograft Line
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