Zusammenfassung
Virostatica wie Idoxuridin, Vidarabin, Amantadin, Tromantadin, Äthyldesoxyuridin, Inosiplex, Acyclovir, Phosphonoformiat, Bromovinyldesoxyuridin und Fluordesoxyarabinofuranosyljodcytosin werden in bezug auf Angriffspunkte, Wirkmechanismen, bewiesene Wirkungen und Nebenwirkungen diskutiert. Die klinische Wirksamkeit und mögliche Indikationen werden besprochen. Auf Bedeutung und Zukunftsaspekte wird hingewiesen.
Summary
Antiviral drugs, e.g. Idoxuridine, Vidarabine, Amantadine, Tromantadine, Ethyldesoxyuridine, Inosiplex, Acyclovir, Phosphonoformiate, Bromovinyldesoxyuridine and Fluordeoxyarabinofuranosyljodcyto- sin are discussed in respect to working points, mechanisms of action, prooven effects and side effects. Clinical efficacy and possible indications are referred. Significance and futur aspects are pointed out.
Preview
Unable to display preview. Download preview PDF.
Literatur
Abeles, J H.: Inosiplex in recurrent herpes simplex infections. Lancet 23, 926, (1982).
Ahumada, P M.: Zur Wirksamkeit von Tromantadin bei Herpes simplex. Doppelblindstudie. Ther. Gegenw. 116, 100–108 (1977).
AI Nakib, W, AI Kandari, S, El Khalik, D M A, El Shirbiny, A M.: A randomised controlled study of intravenous Acyclovir (Zovirax) against placebo in adults with chickenpox. J. Infect. 6, Suppl 1, 49–56 (1983).
Balfour, H H jr, Bean, B, Laskin, O L, Ambinder, R F, Meyers, J D, Wade J C.: Acyclovir halts progression of herpes zoster in immunocompromised patients. New Engl. J. Med. 308, 1448–1453 (1983).
Becker, A.: TK-gene and HSV-resistance. Int. Symp. antiviral compounds and wound healing Hamburg 14. 16. June (1983).
Borelli, S, Gehrken, H.: Therapeutische Erfahrungen bei Herpes simplex-Erkrankungen mit Tromantadin-HCl im Doppelblindversuch. Schweiz. Rdsch. Med. (Praxis) 65, 108–110 (1976).
Brigden, S, Whiteman, P.: The mechanism of action, pharmacokinetics and toxicity of Acyclovir - a review. J. Infect. 6, Suppl 1, 3–9 (1983).
Bryson, Y J, Dillon, M, Lovett, M, Acuna, G, Taylor, S, Cherry, J D.: Treatment of first episodes of genital herpes simplex virus infection with oral Acyclovir. A randomized double-blind controlled trial in normal subjects. New Eng. J. Med. 308, 916–921 (1983).
Bunta, S, Peris, Z.; Immunstimulierende Zostertherapie (Dreijährige Erfahrungen mit Inosiplex). Z. Hautkr. 56 (22), 1457–1466 (1982).
Cheng, Y, Nakayama, K, Derse, D, Bastow, K, Ruth, J, Tan, R, Dutschmann, G, Caradonna, S J, Grill, S.: Herpes virus specific enzymes: properties, physiological roles, and pharmacological implications. In: Herpesvirus. Clinical, pharmacological and basic aspects. Proc. Int. Congr. Ser. Exeerpta Medica 47–56 (1982).
Chilf G N, Runne, U.: Intravenöse Zoster-Behandlung mit Acyclovir bei Patienten mit malignen Systemkrankheiten. Hautarzt 34, Suppl. VI, 336–337 (1983).
de Clercq, E, Zhang, Z X, Sim, I S.: Treat-ment of experimental herpes virus encephalitis with (E)-5-(2-bromovinyl)-2’-deoxyuridine in mice. Antimicrob. Agents Chemother. 22, 421–425 (1982).
Corey, L, Benedetti, J, Critchlow, C, Mertz, G, Douglas, J, Fife, K, Fahnlander, A, Remington, M L, Winter, C, Dragavon, J.: Treatment of primary firstepisode genital herpes simplex virus infections with acyclovir: results of topical, intravenous and oral therapy. J. antimicrob. Chemother. 12, Suppl B, 79–88.(1983).
Corey, L, Fife, K H, Benedetti, J K, Winter, CA, Fahnlander, A, Connor, J D.: Intravenous acyclovir for the treatment of primary genital herpes. Ann. intern. Med. 98, 914–921 (1982).
Corey, L, Holmes, K K, Benedetti, J, Critchlow, C.; Clinical course of genital herpes. In: Nahmias, A J, Dowdle, W R, Schinazi, R F. eds. The human herpes viruses: an interdisciplinary perspective. Elsevier New York pp 496–502.(1981).
Crane, L R, Sunstrum, J C, Lerner, A M.: Combination therapy of experimental infection with herpes simplex virus, type 2. Clin. Res. 31, 541 A (1983).
Crumpacker, C S, Schnipper, L E, Kowalsky, P N, Sherman, D M.: Resistance of herpes simplex virus to adenine arabinoside and E-5-(2-bromovinyl)2’-deoxyuridine: A physical analysis. J. infect. Dis. 146, 167–172 (1982).
Crumpacker, C S, Schnipper, L E, Marlowe, S T, Kowalsky, P N, Hershey, B J, Levin, M J.: Resistance to antiviral drugs of herpes simplex virus isolated from a patient treated with acyclovir (1982).
Daksis, JI, Priemer, M M, Chan, V L.: Isolation and preliminary characterization of a phosphonoacetic acid-resistant and temperature-sensitive mutant of herpes simplex virus type 1. J. Virol. 42, 20–29 (1982).
Dawber, R P R.: Idoxuridine in herpes zoster. Further evaluation of intermittent topical therapy. Brit. med. J. 2, 526–529 (1974).
Field, H J.: Drug resistance in herpes simplex virus. In: Herpesvirus. Clinical, pharmacological and basic aspects. Proc. Int. Congr. Ser. Experta Medica 205–210.(1982).
Fiddian, A P, Yeo, J M, Stubbings, R, Dean, D.: Successful treatment of herpes labialis with topical acyclovir. Brit. med. J. 286, 1699–1701 (1983).
Galbraith, A W: Prevention of postherpetic neuralgia by amantadine hydrochloride (Symmetrel). Brit. J. clin. Pract. 37, 304–306 (1983).
Galli, M, Lazzarin, A, Moroni, M, Zanussi, C: Inosiplex in recurrent herpes simplex infections. Lancet II, 331–332.(1982).
Gauri, K K, Wassilew, S W: Chemotherapie bei Virus-Erkrankungen. Offizin. Pharm. 26–42 (1983).
Gluckmann, E, Devergie, A, Melo, R, Nebout, T, Lotsberg, J, Zhao, X M.: Prophylaxis of herpes infections after bone -marrow transplantation by oral acyclovir. Lancett II, 706–708 (1983).
Gould, J M, Chessells, J M, Marshall, W C, Mendrick, G D W: Acyclovir in herpesvirus infections in children: Experience in an open study with particular reference to safety. J. Infect. 5, 283 -289.(1982).
Hann, IM, Prentice, H G, Blacklock, H A, Ross, M G R, Brigden, D, Rosling, A E.: Acyclovir prophylaxis against herpes virus infections in severely immuncompromised patients: Randomised double blind trial. Brit. med. J. 287, 384–388 (1983).
Heidemann, E, Wilms, K, Treuner, J, Niethammer, D.: Fibroblasten-Interferon zur Behandlung des Herpes zoster. Eine Pilotstudie. Dtsch. med. Wschr. 107, 695–697 (1982).
Hellgren, L, Herrmann, L S.: Tromantadine hydrochloride in the treatment of herpes simplex. Dermato-lógica (Basel) 167, 267–272 (1983).
Hofschneider, P H, Obert, HJ.: Vorläufige klinische Erfahrungen mit humanem Fibroblasteninterferon in der Bundesrepublik Deutschland. Verh. Dtsch. Ges. inn. Med. 507- 512.(1982).
Janz, C, Wigand, R.: Combined interaction of antiherpes substances and Interferon beta on the multiplication of herpes simplex virus. Arch. Virol. 73, 135–143 (1982).
Juel-Jensen, B E, Khan, J A, Pasvol, G.: Highdose intravenous acyclovir in the treatment of zoster: A doubleblind placebo-controlled trial. J. Infect. 6, Suppl 1, 31–36 (1983).
Kaufman, E.: New understanding of ocular herpetic disease. Amer. J. Ophthal. 94, 119–121 (1982).
Krasny, H C, Liao, S H T, Good, S S.: Oral pharmacokinetics and metabolism of the prodrug of acyclovir. A134U, in humans. Clin. Pharmacol. Ther. 33, 256 (1983).
Kumor, K M, Woo, J, Conklin, R.: Renal function in immunocompromised patients receiving acyclovir for herpes virus infections. Clin. Res. 30, 253 A (1982).
Larkin, M, Ogilvie, M, Mill, J I.: Effect of low dose acyclovir (5 mg/kg) on virus shedding, interferon and humoral immunity in herpes zoster. J. antimicrob. Chemother. 12, 79–87 (1983).
Leyland, J B, Donnelly, H, Myskowski, P, Donner, A, Groshen, S, Lopez, C.: FIAC, a potent new antiviral agent: Therapeutic superiority over adenine arabinoside (ARA-A) against varicella zoster infections in immunosuppressend patients. Clin. Res. 31, 369A (1983).
Leyland, J B, Feinberg, A, Vidal, P, Fanucchi, M, Williams, L, Young, C.: Human metabolism of 24-fluoro-5-jodo-l beta-D-arabinosylcytosine (FIAC). Proc. Amer. Ass. Cancer Res. 24, 136 (1983).
Madgal, P C, Uyttebroeck, W, de Clercq, E, Missotten, L.: Oral and topical treatment of experimental herpes simplex iritis with bromovinyldeoxyuridine. Arch. Ophthal. (Chicago) 100, 1337–1340 (1982).
Mill, J, Maonald, D R, Fall, C, Donald, G, Mendrick, W, Copplestone, A.: Intravenous acyclovir in acute herpes zoster infection. J. Infect. 6, 157–151 (1983).
Mindel, A, Sutherland, S.: Genital herpes - the disease and this treatment in-cluding intravenous acyclovir. J. antimicrob. Chemother. 12, Suppl. B, 51- 59.(1983).
Nasemann, Th.: Viruskrankheiten der Haut, der Schleimhäute und des Genitale. Thieme Stuttgart (1974).
Oberg, B.: Antiviral effects of phosphonoformiate (PFA, Foscarnet Sodium). Pharmacol. Ther. 10, 387–415 (1983).
Orenstein, WA.: Prophylaxis of varicella in high-risk children: Doseresponse effect of zoster immune globulin. J. Pediat. (St. Louis) 98, 368–373 (1981).
Peterslund, NA, Black, F T, Tauris, P.: Impaired renal function after injections of acyclovir. Lancet I, 243–244 (1983).
Preiksaitis, J K, Rosno, S, Grumet, C, Merigan, T C.: Infections due to herpesviruses in cardiac transplant recipients: Role of the donor heart and immunosuppressive therapy. J. infect. Dis. 147, 974–981. (1983).
Prentice, H G, Hann, I M.: Prophylactic studies against herpes infections in severely immunocompromised patients with acyclovir. J. Infect. 6, Suppl. 1, 17–21 (1983).
Prober, C G, Kirk, L E, Keeney, R E.: Acyclovir therapy of chickenpox in immunsuppressed children: A collaborative study. J. Pediat. (St. Louis) 101, 622- 625.(1982).
Raab, B, Lorincz, A L.: Topical acyclovir caution. J. Amer. Acad. Derm. 124 (1983).
Reichman, R C, Badger, G J, Guinan, M E, Nahmias, A J, Keeney, R E, Davis, L G.: Topically administered acyclovir in the treatment of recurrent herpes simplex genitalis: A controlled trial. J. infect. Dis. 147, 336–340 (1983).
Reichman, R C, Badger, G J, Mertz, G J, Corey, L, Richman, D, Oxman, M.: Patient-initiated therapy of recurrent herpes simplex genitalis with orally administered acyclovir. Clin. Res. 31, 373A (1983).
Rosenthal, K S, Sokol, M S, Ingram, R L, Subramanian, R, Fort, R C: Tromantadine: Inhibitor of early and late events in herpes simplex virus replication. Antimicrob. Agents Chemother. 22, 1031–1136 (1982).
Schneider, W, Schneider, B.: Wirkungen und Nebenwirkungen der topischen Therapie bei Herpes simplex-Infektionen der Haut. Therapiewoche 32, 5352–5358 (1982).
Schoeßnius, H H.: Moderne Therapie des Herpes simplex. Med. Klin. 78, 91–94 (1983).
Shigeta, S, Yokota, T, Iwabuchi, T, Baba, M, Konno, K, Ogata, M.: Comparative efficacy of antiherpes drugs against various strains of varicella zoster virus. J. infect. Dis. 147, 576–584 (1983).
Sibrack, C D, Gutman, L T, Wilfert, C M, Maren, C, Glair, M G St, Keller, P M.: Pathogenicity of acyclovir-resistant herpes simplex virus type 1 from an immunodeficient child. J. infect. Dis. 146, 673–682 (1982).
Silvestri, D L, Corey, L, Holmes, K K: Ineffectivness of topical idoxuridine in dimethylsulfoxide for therapy for genital herpes. JAMA 248, 953–959 (1982).
Steele, R W, Keeney, R E, Bradsher, R W, Moses, E B, Soloff, B L.: Treatment of varicellazoster meningoencephalitis with acyclovir-demonstration of virus in cerebrospinal fluid by electron microscopy. Amer. J. clin. Path. 80, 57–60 (1983).
Stiehm, E R, Kronenberg, L H, Rosenblatt, H M, Bryson, Y, Merigan, TC.: Interferon: Immunobiology and clinical significance. Ann. intern. Med. 96, 80–93 (1982).
Straus, S, Seidlin, M, Takiff, H, Bachrach, S, Di Giovanna, J, Western, K: Suppression of recurrent genital herpes with oral acyclovir. Clin. Res. 31, 543A (1983).
Swart, R N J, Vermeer, B J, Meer, J W M van der, Enschede, F A J, Versteeg, J.: Treatment of eczema herpeticum with acyclovir. Arch. Derm. 119, 13–16 (1983).
Teh, C Z, Sacks, S L.: Susceptibility of recent clinical isolates of herpes simplex virus to 5-ethyl-2/-deoxyuridine: Preferential inhibition of herpes simplex virus type 2. Antimicrob. Agents Chemother. 23, 637–640 (1983).
Theml, H, Siegert, W, Ziegler, H W L, Huhn, D.: Interferon, eine der interessantesten biologischen Substanzen, aber kein Allheilmittel. Med. Klin. 77, 132–139 (1982).
Thin, R N, Nabarro, J M, Parker, J D, Fiddian, A P.: Topical acyclovir in the treatment of initial genital herpes. Brit. J. vener. Dis. 59, 116–119 (1983).
Walle, van der H B, Malten, K E, Wargemakers, T H.: Contactallergie voor tromantadine (Viru Merz) bij de Behandeling van Herpes simplex infecties. Ned. T. Geneesk. 126, 1033–1035 (1982).
Wallin, J, Lernestedt, L O, Lycke, E.: Treatment of recurrent herpes labialis with trisodium phosphonoformiate. Antivirals 8, 1361–1363 (1979).
Wassilew, S W.: Acyclovir (Zovirax®). Arzneimittelther 1. Jahrg, 4 (1983).
Wassilew, S W.: Möglichkeiten und Grenzen der Chemotherapie bei Erkrankungen durch das Herpes simplex- und das Varicella-Zoster-Virus. Hautarzt 24, 1–5 (1983).
Whitley, R J, Soong, S J, Hirsch, M S, Karchmer, A W, Dolin, R, Calasso, G, Dunnick, J K, Alford, CA.: Herpes simplex encephalitis. Vidarabine therapy and diagnostic problems. New Engl. J. Med. 304, 313–318 (1981).
Whitley, R J, Ch’ien, L T, Dolin, R, Galasso, G, Alford, CA, and editors of the Collaborative Study Group.: Adenine arabinoside therapy of herpes zoster in the immunosuppressed: NIAID collaborative antiviral study. New Engl. J. Med. 294, 1193–1199 (1976).
Whitley, R J, and the NIAID Collaborative Antiviral Study Group: Interim summary of mortality in herpes simplex encephalitis and neonatal herpes simplex virus infections: vidarabine versus acyclovir. J. antimicrob. Chemother. 12, Suppl. B, 105–112 (1983).
Wildenhoff, K E, Esmann, V, Ipsen, J, Harving, H, Peterslund, N A, Schonhey der, H.: Treatment of trigeminal and thoracic zoster with idoxuridine. Scand. J. infect. Dis. 13, 251–262.(1981).
Yeo, J M, Fiddian, A P.: Acyclovir in the management of herpes.labialis. J. antimicrob. Chemother. 12, Suppl. B, 95–103 (1983).
Yokota, T, Shigeta, S, Iwabuchi, T, Ogata, M, Takami, Z.: Mutant strain of varicella zoster virus deficient in thymidine kinase- inducing activity. In: Herpesvirus. Clinical pharmacological and basic aspects. Proc. Excerpta Medica Int. Congr. Ser. pp 102–105 (1982).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Wassilew, S.W., Nasemann, T. (1987). Virostatika in der Dermatologie. In: Hornstein, O.P., Hundeiker, M., Schönfeld, J. (eds) Neue Entwicklungen in der Dermatologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73248-5_8
Download citation
DOI: https://doi.org/10.1007/978-3-642-73248-5_8
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-18636-6
Online ISBN: 978-3-642-73248-5
eBook Packages: Springer Book Archive