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Strahlentherapie der Mycosis fungoides und des Sézary-Syndroms

  • Arthur Wiskemann

Zusammenfassung

Die Erkennung der Mycosis fungoides und des Sézary-Syndroms als malignes T-Zell-Lymphom ist die Grundlage neuer Klassifikationen und Therapiekonzepte. Die klassische Röntgentherapie wird heute vorzugsweise bei tumorösen Infiltraten als Weichstrahltherapie und bei flachen generalisierten Infiltraten als Fernbestrahlung durchgeführt.

Die letztere Methode ist weitgehend durch die PUVA-Behandlung, durch die lokale Chemotherapie mit Stickstofflost und durch die Ganzhaut-Elektronenbestrahlung verdrängt worden. Eine lebensverlängernde Wirkung der genannten Therapien ist fraglich. Durch Kombination der Ganzhaut-Elektronentherapie mit Stickstofflost oder systemisch verabreichten Cytostatica sucht man die Ergebnisse in fortgeschrittenen Krankheitsstadien oder als aggressive Therapie auch in frühen Stadien zu verbessern.

Summary

The perception of mycosis fungoides and the Sézary syndrome as malignant T-cell lymphoma is the base of new classifications and concepts for therapy. At present time x-ray therapy is performed as soft x-ray therapy of tumorous Mf infiltrates or as tele-roentgentherapy of flat infiltrates. The latter method has been largely replaced by photochemotherapy, by topical chemotherapy with nitrogen mustard and by electron beam therapy. Prolonged survival by these managements is questionable. Efforts are made to improve the therapeutic results by the combination of electron beam therapy with local or systemic chemotherapy in advanced stages, or as an aggressive therapy in early stages of the disease.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • Arthur Wiskemann
    • 1
  1. 1.Abteilung für Dermatologische Radiologie der Universitäts-Hautklinik HamburgHamburg 20Deutschland

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