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New Hypothesis for the Ontogenesis of Nevocytic Nevi

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Neue Entwicklungen in der Dermatologie

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Zusammenfassung

Die Autoren unterbreiten ein neues Konzept zum Verständnis der Ontogenese von Naevuszellnaevi mit der Hypothese, daß Naevuszellen als mutierte Zellinien von Neuralleisten-Zellen, Melanoblasten, primordialen Melanocyten und reifen Melanocyten interpretiert werden können. Es wird angenommen, daß bei diesen mutierten Zellen primär die Affinität zu den Keratinocyten vermindert wird. Die Hypothese steht mit Beobachtungen an verschiedenen prä- und postnatalen Naevuszellnaevi in Einklang.

Summary

A new hypothesis for the ontogenesis of nevocytic nevi is proposed, saying that the nevus cells are mutant cell lines of neural crest cells, melanoblasts, primordial melanocytes and melanocytes, in which a mutation happened in the gene(s) which is (are) responsible for the expression of cell affinity to keratinocytes. Dependent on the time of the somatic mutation, a giant, medium-sized or small-sized congenital nevocytic nevus or an acquired nevocytic nevus develops.

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Abbreviations

ANN:

acquired nevocytic nevi

CAM:

cell adhesion molecule

CNN:

congenital nevocytic nevi

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Author information

Authors and Affiliations

  1. Department of Dermatology, University Hospital of Zurich, Gloriastraße 31, 8091, Zurich, Switzerland

    O. Maie & B. V. Schneider

Authors
  1. O. Maie
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  2. B. V. Schneider
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  3. Prof. Dr. Dr. h.c. U. W. Schnyder
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Editor information

Editors and Affiliations

  1. Erlangen, Deutschland

    O. P. Hornstein

  2. Münster-Hornheide, Deutschland

    M. Hundeiker

  3. Mannheim, Deutschland

    J. Schönfeld

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© 1987 Springer-Verlag Berlin Heidelberg

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Maie, O., Schneider, B.V., Schnyder, U.W. (1987). New Hypothesis for the Ontogenesis of Nevocytic Nevi. In: Hornstein, O.P., Hundeiker, M., Schönfeld, J. (eds) Neue Entwicklungen in der Dermatologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73248-5_2

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  • DOI: https://doi.org/10.1007/978-3-642-73248-5_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-18636-6

  • Online ISBN: 978-3-642-73248-5

  • eBook Packages: Springer Book Archive

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