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New Hypothesis for the Ontogenesis of Nevocytic Nevi

  • O. Maie
  • B. V. Schneider
  • U. W. Schnyder

Zusammenfassung

Die Autoren unterbreiten ein neues Konzept zum Verständnis der Ontogenese von Naevuszellnaevi mit der Hypothese, daß Naevuszellen als mutierte Zellinien von Neuralleisten-Zellen, Melanoblasten, primordialen Melanocyten und reifen Melanocyten interpretiert werden können. Es wird angenommen, daß bei diesen mutierten Zellen primär die Affinität zu den Keratinocyten vermindert wird. Die Hypothese steht mit Beobachtungen an verschiedenen prä- und postnatalen Naevuszellnaevi in Einklang.

Abbreviations in the text:

ANN

acquired nevocytic nevi

CAM

cell adhesion molecule

CNN

congenital nevocytic nevi

Summary

A new hypothesis for the ontogenesis of nevocytic nevi is proposed, saying that the nevus cells are mutant cell lines of neural crest cells, melanoblasts, primordial melanocytes and melanocytes, in which a mutation happened in the gene(s) which is (are) responsible for the expression of cell affinity to keratinocytes. Dependent on the time of the somatic mutation, a giant, medium-sized or small-sized congenital nevocytic nevus or an acquired nevocytic nevus develops.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • O. Maie
    • 1
  • B. V. Schneider
    • 1
  • U. W. Schnyder
  1. 1.Department of DermatologyUniversity Hospital of ZurichZurichSwitzerland

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