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Die Bedeutung von α-MSH für physiologische und pathophysiologische Vorgänge beim Menschen

  • P. Altmeyer
  • R. N. Bartelt
  • L. Woller
  • G. N. Chilf
  • N. Bühles
  • H. Holzmann
Chapter

Zusammenfassung

Durch rädioimmimologische Methoden konnte die Existenz des Melanocyten stimulierenden Hormons in der menschlichen Hypophyse nachgewiesen werden. Nach dem heutigen Erkenntnisstand kommt hauptsächlich dem α-MSH eine physiologische Bedeutung zu.

Anhand der vorliegenden Literatur und eigener Untersuchungen wird gezeigt, daß exogene Faktoren, Biorhythmen und einige Krankheitsprozesse die Sekretion von α-MSH regulieren. Insbesonders können UVA-Strahlen bei hellhäutigen Personen den α-MSH-Plasmaspiegel steigern.

Zahlreiche Experimente mit Melanomzellkulturen zeigten den Einfluß von α-MSH auf die Funktion und Proliferation der Melanomzelle. Die vorliegenden Erkenntnisse über die Bedeutung von α-MSH beim Menschen können daher einen Beitrag zur Diskussion über die Entstehung des malignen Melanoms liefern.

Summary

The existence of alpha melanocyte stimulating hormone in the pituitary of man could be proved by radioimmundlogical methods. According to the present understanding mainly äMSH has a physiological importance.

It is demonstrated by the literature and by the own investigations that the secretion of ä-MSH is regulated by exogene factors, biorhythm and some diseases. Specially UV-A rays may cause an increase of ä-MSH levels in plasma in persons with light skin.

Many experiments with melanoma cell cultures indicate the influence of ä-MSH on the function and the proliferation-rate of the melanoma cell. The present knowledge about the meaning of ä-MSH in man therefore may deliver a contribution in the discussion about the induction of the malignant melanoma.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • P. Altmeyer
    • 1
    • 2
  • R. N. Bartelt
    • 1
    • 3
  • L. Woller
    • 1
  • G. N. Chilf
    • 1
  • N. Bühles
    • 1
  • H. Holzmann
    • 1
  1. 1.Zentrum der DermatologieVenerologie der Universitätskliniken der J. W. Goethe-UniversitätFrankfurt/Main 70Deutschland
  2. 2.St. Josef-HospitalUniversitäts-HautklinikBochum 1Deutschland
  3. 3.Zentrum DermatologieVenerologie der Universitätskliniken Frankfurt/M.Frankfurt/M. 70Deutschland

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