Eicosanoids and Diabetic Hypertension
Hypertension is more common in juvenile onset diabetes than in the normal population and is considered to be a major risk factor in this group of patients (Christlieb et al. 1981). More than 2.5 million Americans suffer from diabetes associated with hypertension (Working Group on Hypertension in Diabetes 1987). The development of the vascular complications of diabetes, namely diabetic macro- and microangiopathy and the prothrombotic stage, eventually combined with diabetic hypertension, might be facilitated by a more general disturbance in the defence mechanisms of the body, being related to insulin deficiency. This involves alterations in eicosanoid production that are not only important for control of insulin secretion (Rösen and Hohlfeld 1985; Robertson 1986) but also for the vascular and thrombotic complications of the disease. This paper reviews the present evidence for a contribution of disturbed eicosanoid production to the vascular complications in diabetes mellitus with particular emphasis on hypertension.
KeywordsDiabetic Subject Diabetic Ketoacidosis Tail Artery Eicosanoid Production Lipoxygenase Product
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